Detailed information of TA system TA141759

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-Phd
• Location: 6165..6811
• Replicon: plasmid pTHAF35_c
• Accession: NZ_CP045383
• Organism: Labrenzia sp. THAF35

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FIU93_RS30945
• Protein ID: WP_062492135.1
• Coordinates: 6404..6811 (+)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FIU93_RS30940
• Protein ID: WP_082809967.1
• Coordinates: 6165..6407 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FIU93_RS30925	2372..3565	+	1194	WP_088665297.1	plasmid partitioning protein RepA	-
FIU93_RS30930	3569..4570	+	1002	WP_152508057.1	plasmid partitioning protein RepB	-
FIU93_RS30935	4794..6050	+	1257	WP_062492133.1	replication protein C	-
FIU93_RS30940	6165..6407	+	243	WP_082809967.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FIU93_RS30945	6404..6811	+	408	WP_062492135.1	type II toxin-antitoxin system VapC family toxin	Toxin
FIU93_RS30950	7036..7242	+	207	WP_062492137.1	antitoxin VbhA family protein	-
FIU93_RS30955	7307..9025	+	1719	WP_152508058.1	Fic family protein	-
FIU93_RS30960	9301..9645	+	345	WP_062492226.1	DUF736 family protein	-
FIU93_RS30965	9950..10237	+	288	WP_062492139.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..70393	70393

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-118)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-50)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 15120.26 Da
• Isoelectric Point: 5.2058

>T141759 WP_062492135.1 NZ_CP045383:6404-6811 [Labrenzia sp. THAF35]
MIYVLDTNVITAARRAERAPKVAAWLSDKPEETLYVSVVTLGEIERGIRLQERRNMDFAKHLRQWLDRTVSMFGDRLLEF
TASDALCWGELSARIGHNGADLMIAAQALTRNGWVVTGNASDFEPTGVQLVDPFV

Nucleotide

• Length: 408 bp

>T141759 NZ_CP060083:c1969479-1969105 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9002.25 Da
• Isoelectric Point: 10.4416

>AT141759 WP_082809967.1 NZ_CP045383:6165-6407 [Labrenzia sp. THAF35]
MISLQDAKNRFSAVVEAAMAGRPQEVSRRGKPAVVVISSEEYRRLLREAKGRRESFADHVLSFPGEGIERSKVTPRDVEF

Nucleotide

• Length: 243 bp

>AT141759 NZ_CP060083:c1969936-1969568 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA