Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 5344514..5345753 Replicon chromosome
Accession NZ_CP045380
Organism Labrenzia sp. THAF35

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FIU93_RS24600 Protein ID WP_152507699.1
Coordinates 5345133..5345753 (+) Length 207 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FIU93_RS24595 Protein ID WP_152507040.1
Coordinates 5344514..5345083 (+) Length 190 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FIU93_RS24575 5340562..5341410 - 849 WP_023000192.1 phosphonate ABC transporter, permease protein PhnE -
FIU93_RS24580 5341593..5342507 - 915 WP_023000193.1 phosphonate ABC transporter substrate-binding protein -
FIU93_RS24585 5342566..5343399 - 834 WP_152507698.1 phosphonate ABC transporter ATP-binding protein -
FIU93_RS24590 5343799..5344425 + 627 WP_152507039.1 chloramphenicol acetyltransferase -
FIU93_RS24595 5344514..5345083 + 570 WP_152507040.1 helix-turn-helix transcriptional regulator Antitoxin
FIU93_RS24600 5345133..5345753 + 621 WP_152507699.1 HD domain-containing protein Toxin
FIU93_RS24605 5345893..5346264 + 372 WP_152507041.1 STAS/SEC14 domain-containing protein -
FIU93_RS24610 5346363..5347151 - 789 WP_023000199.1 class II glutamine amidotransferase -
FIU93_RS24615 5347168..5348634 - 1467 WP_152507042.1 aminotransferase class V-fold PLP-dependent enzyme -
FIU93_RS24620 5348739..5349200 + 462 WP_152507043.1 Lrp/AsnC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(28-168)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-68)


Sequences

Toxin        


Download         Length: 207 a.a.        Molecular weight: 23063.30 Da        Isoelectric Point: 4.7759

>T141758 WP_152507699.1 NZ_CP045380:5345133-5345753 [Labrenzia sp. THAF35]
MTKTPPSLDLPEISHTRLTGLLDFLQAAEQLKDTLRSGTTTGGRPESTAEHSWRLALMVLLFEPELKEVDLLKLLKLTLV
HDLGEAISGDVPAPLQTPGDDRQERERRDFLTLCEPLPGDVAGELTSLWDEYAAARTVEARLAKAFDKLETMLQHVLMPR
QAPSFYEFNLGYGRDRTDCSALTRQLRDEVDKLTRTMMTGAGREIA

Download         Length: 621 bp

>T141758 NZ_CP060083:1957583-1957837 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 190 a.a.        Molecular weight: 21603.56 Da        Isoelectric Point: 7.3881

>AT141758 WP_152507040.1 NZ_CP045380:5344514-5345083 [Labrenzia sp. THAF35]
MQTETAVLESSLGPSLRRWRVLNRVKQEALAHELGVSQTRISRWESGKSQPDDSDRAKITRLLRARPESAADKALLDLVS
RSAVPVHLVCDLTHRLLAISVPRACEWRAPVSEFLNRPLWRFASEGIRATEHRLTDYGWFEPDAPDIVYRTEHVDFPEMT
IPESIIRISRLPLSDGRFARLVREEQDAA

Download         Length: 570 bp

>AT141758 NZ_CP060083:1957335-1957586 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References