Detailed information of TA system TA141757

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 185385..185928
• Replicon: plasmid pTHAF37_a
• Accession: NZ_CP045373
• Organism: Sulfitobacter sp. THAF37

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: FIU94_RS17705
• Protein ID: WP_152467175.1
• Coordinates: 185385..185684 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: FIU94_RS17710
• Protein ID: WP_093037612.1
• Coordinates: 185677..185928 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FIU94_RS17700	180861..185258	-	4398	WP_152467174.1	strawberry notch family protein	-
FIU94_RS17705	185385..185684	-	300	WP_152467175.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FIU94_RS17710	185677..185928	-	252	WP_093037612.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
FIU94_RS17715	185979..186623	-	645	WP_152467176.1	hypothetical protein	-
FIU94_RS17720	186730..187206	-	477	WP_027246193.1	hypothetical protein	-
FIU94_RS17725	187208..187591	-	384	WP_027246194.1	hypothetical protein	-
FIU94_RS17730	187695..187967	-	273	WP_152467177.1	hypothetical protein	-
FIU94_RS17735	188085..188465	-	381	WP_071974427.1	DUF3768 domain-containing protein	-
FIU94_RS17740	188592..190763	-	2172	WP_152467178.1	ParB/RepB/Spo0J family partition protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..228730	228730

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-91)

Antitoxin

• Antitoxin ParD (3-74)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11412.02 Da
• Isoelectric Point: 7.0610

>T141757 WP_152467175.1 NZ_CP045373:c185684-185385 [Sulfitobacter sp. THAF37]
MRRIHHSQAAKSDLVDIWVETHGQWGEAQADRYLDDIDRALKGLIANPQMGSDCSDLLQGARKLITGRHLVFYELDPDRI
FVIRVLHQSMDVPRHLRPT

Nucleotide

• Length: 300 bp

>T141757 NZ_CP060083:1957335-1957586 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9163.36 Da
• Isoelectric Point: 5.1425

>AT141757 WP_093037612.1 NZ_CP045373:c185928-185677 [Sulfitobacter sp. THAF37]
MASTSVTLGPHWDEFIALMLKEGRYGSTSELIRASLRLMEEQEGQRARLRVALMEGKQSGDAGPLDMDEIKREARSRSGA
PDA

Nucleotide

• Length: 252 bp

>AT141757 NZ_CP060083:1957583-1957837 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA