Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 4160856..4161403 Replicon chromosome
Accession NZ_CP045367
Organism Marinobacter sp. THAF39

Toxin (Protein)


Gene name relE Uniprot ID A0A5P9ER54
Locus tag FIU96_RS19115 Protein ID WP_072675918.1
Coordinates 4160856..4161158 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U7FV42
Locus tag FIU96_RS19120 Protein ID WP_022990189.1
Coordinates 4161146..4161403 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FIU96_RS19090 4156964..4158733 - 1770 WP_152439483.1 DUF4394 domain-containing protein -
FIU96_RS19095 4158921..4159661 - 741 WP_152439484.1 transporter substrate-binding domain-containing protein -
FIU96_RS19100 4159773..4160174 - 402 WP_152439485.1 GFA family protein -
FIU96_RS19105 4160207..4160470 - 264 WP_152439486.1 Txe/YoeB family addiction module toxin -
FIU96_RS19110 4160467..4160709 - 243 WP_152439487.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FIU96_RS19115 4160856..4161158 - 303 WP_072675918.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FIU96_RS19120 4161146..4161403 - 258 WP_022990189.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FIU96_RS19125 4161578..4162225 - 648 WP_152480532.1 hypothetical protein -
FIU96_RS19130 4162325..4162621 - 297 WP_152439647.1 hypothetical protein -
FIU96_RS19135 4162698..4163312 - 615 WP_152439489.1 hypothetical protein -
FIU96_RS19140 4163419..4163769 - 351 WP_152439490.1 hypothetical protein -
FIU96_RS19145 4163974..4164483 - 510 WP_152439491.1 hypothetical protein -
FIU96_RS19150 4164622..4164891 - 270 WP_152439492.1 hypothetical protein -
FIU96_RS19155 4165030..4165518 - 489 WP_152439493.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11632.35 Da        Isoelectric Point: 4.3363

>T141756 WP_072675918.1 NZ_CP045367:c4161158-4160856 [Marinobacter sp. THAF39]
MAEVIWTEPALQELDAIAEYIALDNPAAASYLVQEVFDKTERLENFPQSGRIPPELPNSVYREVVVPPCRIFYREDEKRV
LILYVMREERQLRAFMLGSS

Download         Length: 303 bp

>T141756 NZ_CP060083:1044007-1044342 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9887.41 Da        Isoelectric Point: 8.5042

>AT141756 WP_022990189.1 NZ_CP045367:c4161403-4161146 [Marinobacter sp. THAF39]
MKVELVTNLKRQATKILADLHLSKEPVLITEHGQPSAYLVDVQDYEFMQRRLELLEGLSRGERAVLEGRTYSQSEAREKM
SKWLK

Download         Length: 258 bp

>AT141756 NZ_CP060083:1043759-1044007 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5P9ER54

Antitoxin

Source ID Structure
AlphaFold DB A0A1I1I6C4

References