Detailed information of TA system TA141755

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): BrnTA/BrnT_toxin-BrnA
• Location: 2706888..2707305
• Replicon: chromosome
• Accession: NZ_CP045367
• Organism: Marinobacter sp. THAF39

Toxin (Protein)

• Gene name: brnT
• Uniprot ID: -
• Locus tag: FIU96_RS12560
• Protein ID: WP_152438564.1
• Coordinates: 2707126..2707305 (-)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: brnA
• Uniprot ID: -
• Locus tag: FIU96_RS12555
• Protein ID: WP_152438563.1
• Coordinates: 2706888..2707142 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FIU96_RS12530	2703118..2703807	-	690	WP_152438559.1	hypothetical protein	-
FIU96_RS12535	2703844..2704167	-	324	WP_152438560.1	nucleotidyltransferase domain-containing protein	-
FIU96_RS12540	2704526..2705998	+	1473	WP_152438561.1	flagellin	-
FIU96_RS12545	2706202..2706441	+	240	WP_061333890.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
FIU96_RS12550	2706443..2706829	+	387	WP_152438562.1	type II toxin-antitoxin system VapC family toxin	-
FIU96_RS12555	2706888..2707142	-	255	WP_152438563.1	BrnA antitoxin family protein	Antitoxin
FIU96_RS12560	2707126..2707305	-	180	WP_152438564.1	BrnT family toxin	Toxin
FIU96_RS12565	2707452..2708852	-	1401	WP_152438565.1	plasmid pRiA4b ORF-3 family protein	-
FIU96_RS12570	2709035..2709268	+	234	WP_152438566.1	DUF2281 domain-containing protein	-
FIU96_RS12580	2709632..2711635	+	2004	WP_152438567.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (3-51)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (24-77)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6815.96 Da
• Isoelectric Point: 7.9630

>T141755 WP_152438564.1 NZ_CP045367:c2707305-2707126 [Marinobacter sp. THAF39]
MLTAIDDLYAYGEERWIAIGLIKQFIGVVVYVERCGDAVRIISARKAARREVRLYEQNI

Nucleotide

• Length: 180 bp

>T141755 NZ_CP060083:928405-928812 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9925.17 Da
• Isoelectric Point: 7.0135

>AT141755 WP_152438563.1 NZ_CP045367:c2707142-2706888 [Marinobacter sp. THAF39]
MNRTSKTDWQRMAEHGDEQIDTSDIPELDDAFFERAELRLPAKQPVTLRIDEDVLAWFKAQGKGYQTRINKLLRQYMGSQ
VNRR

Nucleotide

• Length: 255 bp

>AT141755 NZ_CP060083:928158-928424 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA