Detailed information of TA system TA141754

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /BrnT(toxin)
• Location: 2411937..2412459
• Replicon: chromosome
• Accession: NZ_CP045367
• Organism: Marinobacter sp. THAF39

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: FIU96_RS11165
• Protein ID: WP_152438361.1
• Coordinates: 2412196..2412459 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A7Z0LM09
• Locus tag: FIU96_RS11160
• Protein ID: WP_074396173.1
• Coordinates: 2411937..2412206 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FIU96_RS11130	2407299..2407631	-	333	WP_152438355.1	hypothetical protein	-
FIU96_RS11135	2407708..2408160	-	453	WP_152438356.1	hypothetical protein	-
FIU96_RS11140	2408313..2409116	-	804	WP_152438357.1	IS21-like element helper ATPase IstB	-
FIU96_RS11145	2409113..2410297	-	1185	WP_152438358.1	IS21 family transposase	-
FIU96_RS11150	2410769..2411215	-	447	WP_152438359.1	hypothetical protein	-
FIU96_RS11155	2411324..2411902	-	579	WP_152438360.1	hypothetical protein	-
FIU96_RS11160	2411937..2412206	-	270	WP_074396173.1	CopG family transcriptional regulator	Antitoxin
FIU96_RS11165	2412196..2412459	-	264	WP_152438361.1	BrnT family toxin	Toxin
FIU96_RS11170	2412606..2413253	-	648	WP_152438362.1	hypothetical protein	-
FIU96_RS11175	2413353..2413649	-	297	WP_152439647.1	hypothetical protein	-
FIU96_RS11180	2413776..2414189	-	414	WP_152438363.1	GNAT family N-acetyltransferase	-
FIU96_RS11185	2414315..2414647	-	333	WP_152438364.1	hypothetical protein	-
FIU96_RS11190	2414744..2415367	-	624	WP_152438365.1	SagB/ThcOx family dehydrogenase	-
FIU96_RS11195	2415442..2416071	-	630	WP_152438366.1	hypothetical protein	-
FIU96_RS11200	2416182..2416601	-	420	WP_152438367.1	hypothetical protein	-
FIU96_RS19985	2416715..2416870	-	156	WP_172972271.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2401779..2427685	25906
	-	flank	IS/Tn	-	-	2408313..2409116	803
	-	inside	Integron	-	-	2404319..2429171	24852

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (6-81)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10310.73 Da
• Isoelectric Point: 7.2036

>T141754 WP_152438361.1 NZ_CP045367:c2412459-2412196 [Marinobacter sp. THAF39]
MDEFEFDDAKSQANLDKHGIDFVAAQRLWKDPYLLEIRAKSEDEPRFLLVGKIGEKHWSAVVTYRDARIRLISVRRSRKK
EVELYES

Nucleotide

• Length: 264 bp

>T141754 NZ_CP060083:c786151-785777 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10021.22 Da
• Isoelectric Point: 4.8838

>AT141754 WP_074396173.1 NZ_CP045367:c2412206-2411937 [Marinobacter sp. THAF39]
MKAKDFDKKFEEGQEDIVDDLDLSSARRVNQEQKRINVDFPAWVVESLDREAARIGVTRQSIIKVWLVERLQAESANKPL
NGDAAGGAH

Nucleotide

• Length: 270 bp

>AT141754 NZ_CP060083:c786609-786241 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A7Z0LM09