Detailed information of TA system TA141751

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 10472..11033
• Replicon: plasmid pTHAF40_d
• Accession: NZ_CP045364
• Organism: Roseivivax sp. THAF40

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FIU97_RS20270
• Protein ID: WP_089963184.1
• Coordinates: 10758..11033 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1N7QLX2
• Locus tag: FIU97_RS20265
• Protein ID: WP_044353023.1
• Coordinates: 10472..10771 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FIU97_RS20240	6216..6425	+	210	WP_040182663.1	hypothetical protein	-
FIU97_RS20245	6512..6901	+	390	WP_152456342.1	DUF3768 domain-containing protein	-
FIU97_RS20250	7059..9041	+	1983	WP_152456344.1	ParB/RepB/Spo0J family partition protein	-
FIU97_RS20255	9118..9711	+	594	WP_152456346.1	regulator	-
FIU97_RS20260	9711..10367	+	657	WP_152456348.1	hypothetical protein	-
FIU97_RS20265	10472..10771	+	300	WP_044353023.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
FIU97_RS20270	10758..11033	+	276	WP_089963184.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FIU97_RS20275	11140..15402	+	4263	WP_152456350.1	strawberry notch family protein	-
FIU97_RS20280	15524..15910	+	387	WP_132464639.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..34238	34238

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-54)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10418.99 Da
• Isoelectric Point: 4.5837

>T141751 WP_089963184.1 NZ_CP045364:10758-11033 [Roseivivax sp. THAF40]
MPNLEWKATAIADLLAIIDYISDDNPDAAQVLKDEIEHKTSLLPERPQMYRAGRVDGTREMVIRPNYIVVYAESLEMVTI
LRVLHAAQQWP

Nucleotide

• Length: 276 bp

>T141751 NZ_CP060083:c602662-602198 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10462.91 Da
• Isoelectric Point: 5.6448

>AT141751 WP_044353023.1 NZ_CP045364:10472-10771 [Roseivivax sp. THAF40]
MPAQTSMLHVRVDDQLKAQASDALAGVGLTLSDAVRILLTRVAAEGGLPAGLTADPDAYDAWFRAKVQEALDDPRPTTPH
AKAMQDAQALIDGKRLAKS

Nucleotide

• Length: 300 bp

>AT141751 NZ_CP060083:c602997-602662 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A1N7QLX2