Detailed information of TA system TA141749

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 3830010..3831207
• Replicon: chromosome
• Accession: NZ_CP045359
• Organism: Pseudomonas sp. THAF42

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: FIU98_RS17765
• Protein ID: WP_152489373.1
• Coordinates: 3830010..3830762 (-)
• Length: 251 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A5P9CAU4
• Locus tag: FIU98_RS17770
• Protein ID: WP_037049292.1
• Coordinates: 3830836..3831207 (-)
• Length: 124 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FIU98_RS17740	3825916..3826833	+	918	WP_152489370.1	alpha/beta fold hydrolase	-
FIU98_RS17745	3826830..3827720	+	891	WP_152489371.1	metal-dependent hydrolase	-
FIU98_RS17750	3827778..3829139	-	1362	WP_167494366.1	DNA recombination protein RmuC	-
FIU98_RS17755	3829320..3829571	-	252	WP_037049286.1	hypothetical protein	-
FIU98_RS17760	3829570..3829866	+	297	WP_152489372.1	hypothetical protein	-
FIU98_RS17765	3830010..3830762	-	753	WP_152489373.1	RES family NAD+ phosphorylase	Toxin
FIU98_RS17770	3830836..3831207	-	372	WP_037049292.1	XRE family transcriptional regulator	Antitoxin
FIU98_RS17775	3831342..3833903	+	2562	WP_152489374.1	YdbH domain-containing protein	-
FIU98_RS17780	3833908..3834099	+	192	WP_037049298.1	YnbE family lipoprotein	-
FIU98_RS17785	3834192..3834530	+	339	WP_037049301.1	YdbL family protein	-
FIU98_RS17790	3834602..3834928	-	327	WP_037049304.1	Grx4 family monothiol glutaredoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (62-207)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (72-121)

Sequences

Toxin

Protein

• Length: 251 a.a.
• Molecular weight: 28179.17 Da
• Isoelectric Point: 8.2660

>T141749 WP_152489373.1 NZ_CP045359:c3830762-3830010 [Pseudomonas sp. THAF42]
MDIWQQCAGERQVRPLRGKLLRMVESQAQVATSQLVDNLAEQALLEDLLENSKPPLPEAAEPLHYLLKTPFRYPPLRWGS
RFGTVHEPSLFYAAQHLQTAMAEAAYYRFVLWNGMLSPPPSGRILSEHSTFEARYRVERGIQLQLPPFDAHAAQLAHPSD
YSVAQRLGAAMRAADIQAFEYRSARCPAGGSNVALYVPQAFAEKRPRNLTAWLCETTGDYVAFKPAQVPGQPRLFRWEQF
LVQGQLPHPA

Nucleotide

• Length: 753 bp

>T141749 NZ_CP060077:c49270-48989 [Escherichia coli]
ATGACCTATGAACTGGCTTTTGACCGCAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAGCTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATATCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCTGTTGGAAGA
AGGGAAAGCAGCGAAGTTTATCAGATTGCAGATATGCGCTGA

Antitoxin

Protein

• Length: 124 a.a.
• Molecular weight: 13598.76 Da
• Isoelectric Point: 10.6604

>AT141749 WP_037049292.1 NZ_CP045359:c3831207-3830836 [Pseudomonas sp. THAF42]
MSALIRSQPDADAVLAKALLNTREQLGLTQQELADIVGVHRSAISRWGEQGGLRPQSKTGELALLLIRAYRALFALFGGN
LQDMRHFLRTENRHLAGVPLQQMGQVQGLVRVVEYLDAIRGKV

Nucleotide

• Length: 372 bp

>AT141749 NZ_CP060077:c49511-49260 [Escherichia coli]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA

Structures

Antitoxin

• AlphaFold DB: A0A5P9CAU4