Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-StbC
Location 1142726..1143387 Replicon chromosome
Accession NZ_CP045359
Organism Pseudomonas sp. THAF42

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FIU98_RS05230 Protein ID WP_152488000.1
Coordinates 1142726..1143145 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FIU98_RS05235 Protein ID WP_152488001.1
Coordinates 1143142..1143387 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FIU98_RS05205 1139578..1140492 + 915 WP_152487997.1 DMT family transporter -
FIU98_RS05210 1140551..1140997 - 447 WP_152487998.1 hypothetical protein -
FIU98_RS24780 1141025..1141198 - 174 WP_172979130.1 hypothetical protein -
FIU98_RS05220 1141606..1142181 + 576 WP_152487999.1 hypothetical protein -
FIU98_RS05225 1142330..1142707 - 378 WP_172979131.1 excalibur calcium-binding domain-containing protein -
FIU98_RS05230 1142726..1143145 - 420 WP_152488000.1 type II toxin-antitoxin system VapC family toxin Toxin
FIU98_RS05235 1143142..1143387 - 246 WP_152488001.1 Arc family DNA-binding protein Antitoxin
FIU98_RS05240 1143576..1143944 - 369 WP_152488002.1 hypothetical protein -
FIU98_RS05245 1144062..1144814 + 753 WP_152488003.1 class I SAM-dependent methyltransferase -
FIU98_RS05250 1144925..1145380 + 456 WP_152488004.1 MerR family transcriptional regulator -
FIU98_RS05255 1145328..1145714 + 387 WP_152488005.1 carboxymuconolactone decarboxylase family protein -
FIU98_RS05260 1146928..1147791 + 864 Protein_1043 integrase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1141606..1166733 25127


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Arc-like DNA binding domain

(13-45)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15121.40 Da        Isoelectric Point: 4.2953

>T141746 WP_152488000.1 NZ_CP045359:c1143145-1142726 [Pseudomonas sp. THAF42]
MILLDTNVLSELMRAKPAPQVLEWVDAQPVGDLVITSITVAEILYGIARMPDGKRKQGLLDVASAMFDEDFAGNILPFDA
DAAVYYAEIAAETEAKRRVVDMADAQIAAIGRLHDAVIATRNIRHFETLGVALVDPWSA

Download         Length: 420 bp

>T141746 NZ_CP060075:3925906-3926184 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTACACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8841.99 Da        Isoelectric Point: 10.4369

>AT141746 WP_152488001.1 NZ_CP045359:c1143387-1143142 [Pseudomonas sp. THAF42]
MAAITIRNLDDDLKAQLRIVAASHGRSMEEEARVIIRQALSRQGKRGGLGSRIHSRFAAVGGADLELPERKDNARAASFD
E

Download         Length: 246 bp

>AT141746 NZ_CP060075:3925643-3925903 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References