Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/HTH_31(antitoxin)
Location 4408603..4409862 Replicon chromosome
Accession NZ_CP045354
Organism Labrenzia sp. THAF82

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FIV00_RS20275 Protein ID WP_152504352.1
Coordinates 4409272..4409862 (+) Length 197 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FIV00_RS20270 Protein ID WP_152502456.1
Coordinates 4408603..4409175 (+) Length 191 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FIV00_RS20240 4403872..4404726 - 855 WP_209006635.1 phosphonate ABC transporter, permease protein PhnE -
FIV00_RS20245 4404796..4405713 - 918 WP_152502452.1 phosphonate ABC transporter substrate-binding protein -
FIV00_RS20250 4405772..4406605 - 834 WP_152502453.1 phosphonate ABC transporter ATP-binding protein -
FIV00_RS20255 4407002..4407628 + 627 WP_152502454.1 chloramphenicol acetyltransferase -
FIV00_RS20260 4407707..4408144 + 438 WP_152502455.1 GFA family protein -
FIV00_RS20265 4408192..4408563 + 372 WP_152504351.1 VOC family protein -
FIV00_RS20270 4408603..4409175 + 573 WP_152502456.1 helix-turn-helix transcriptional regulator Antitoxin
FIV00_RS20275 4409272..4409862 + 591 WP_152504352.1 HD domain-containing protein Toxin
FIV00_RS20280 4409990..4410355 + 366 WP_152502457.1 STAS/SEC14 domain-containing protein -
FIV00_RS20285 4410352..4411149 - 798 WP_152502458.1 class II glutamine amidotransferase -
FIV00_RS20290 4411160..4412626 - 1467 WP_152502459.1 aminotransferase class V-fold PLP-dependent enzyme -
FIV00_RS20295 4412731..4413192 + 462 WP_152502460.1 Lrp/AsnC family transcriptional regulator -
FIV00_RS20300 4413208..4414320 - 1113 WP_173006078.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-146)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-63)


Sequences

Toxin        


Download         Length: 197 a.a.        Molecular weight: 22572.73 Da        Isoelectric Point: 5.0092

>T141740 WP_152504352.1 NZ_CP045354:4409272-4409862 [Labrenzia sp. THAF82]
MDANRLSGLLSFLQAAEQLKDTLRSGTTRKKRPESTAEHTWRLALMVLVFERELEGLDLQRLIKLCLIHDLGEAISGDVP
APSQRQDDDRQERERRDFETLCAPLPKDMRDHLMALWLEYAAAETAEAQLAKAFDKLETMLQHLLMPPGDVIFYEFNLTY
GRERTDFSPLTRQIRDLVDKGTRQIMEDLQNAASRT

Download         Length: 591 bp

>T141740 NZ_CP060075:2910708-2910815 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 191 a.a.        Molecular weight: 21778.78 Da        Isoelectric Point: 9.3518

>AT141740 WP_152502456.1 NZ_CP045354:4408603-4409175 [Labrenzia sp. THAF82]
MKNVPAVLPSSLGLSLRRWRVLNRIKQDVLAHELGVSQSRISRWESGRSHPNHKDCLRITTLLRARADSAADNALLHLVS
RSSEPVHLVCDLTHRLLAMSPAREREWRAPVSEFLHRPLWRFATDGIRSVEHRLADFGWFEPLNDDVVYWTEAADFPEMS
IPESQIRISRLQLSDGSFARLVREESSRAA

Download         Length: 573 bp

>AT141740 NZ_CP060075:c2910652-2910596 [Escherichia coli]
TCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References