Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-CC2985
Location 751598..752147 Replicon chromosome
Accession NZ_CP045354
Organism Labrenzia sp. THAF82

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag FIV00_RS03750 Protein ID WP_152499515.1
Coordinates 751848..752147 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag FIV00_RS03745 Protein ID WP_152499514.1
Coordinates 751598..751858 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FIV00_RS29585 747409..747606 + 198 WP_173005855.1 hypothetical protein -
FIV00_RS03715 747711..748007 + 297 Protein_732 IS6 family transposase -
FIV00_RS03720 748022..748513 + 492 WP_152499435.1 GNAT family N-acetyltransferase -
FIV00_RS03725 748697..748813 + 117 Protein_734 transposase -
FIV00_RS03735 750374..750988 + 615 Protein_736 IS6 family transposase -
FIV00_RS03740 751236..751544 + 309 WP_152499513.1 hypothetical protein -
FIV00_RS03745 751598..751858 + 261 WP_152499514.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
FIV00_RS03750 751848..752147 + 300 WP_152499515.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FIV00_RS03755 752172..752567 - 396 WP_152499516.1 antirestriction protein ArdA -
FIV00_RS03760 752917..754149 - 1233 WP_152499517.1 IS110 family transposase -
FIV00_RS03765 754291..754398 + 108 Protein_742 integrase core domain-containing protein -
FIV00_RS03770 754662..755423 - 762 Protein_743 IS110 family transposase -
FIV00_RS03775 755455..757089 + 1635 WP_152504098.1 ATP-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 748994..754149 5155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-92)

Antitoxin

Antitoxin ParD

(6-71)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11353.91 Da        Isoelectric Point: 6.2144

>T141739 WP_152499515.1 NZ_CP045354:751848-752147 [Labrenzia sp. THAF82]
MAYRLTRKAAEDIQNIFGEGTLMFGEAQAIKYHGKLEACFELLAGNPHISRAREEINPPVHIHPIGSHIIVYSVDEQRDI
LIIRVRHGREDWQDNPIEP

Download         Length: 300 bp

>T141739 NZ_CP060075:c2659328-2659152 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9464.59 Da        Isoelectric Point: 4.5310

>AT141739 WP_152499514.1 NZ_CP045354:751598-751858 [Labrenzia sp. THAF82]
MATMNVSLPDPMKDWVEAQAATGRYANASDYVRDLIRRDQERADKIAQMQKLVSEGLDSGISDQSMADILQSARARMKSA
STDDGL

Download         Length: 261 bp

>AT141739 NZ_CP060075:c2659106-2658690 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References