Detailed information of TA system TA141737

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 1093316..1093861
• Replicon: plasmid pTHAF100_a
• Accession: NZ_CP045351
• Organism: Vibrio aquimaris strain THAF100

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: FIV01_RS19320
• Protein ID: WP_152432577.1
• Coordinates: 1093316..1093612 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: D0III5
• Locus tag: FIV01_RS19325
• Protein ID: WP_000557295.1
• Coordinates: 1093619..1093861 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FIV01_RS19295	1089628..1090350	+	723	WP_152432572.1	hypothetical protein	-
FIV01_RS19300	1090355..1090747	+	393	WP_172971881.1	ester cyclase	-
FIV01_RS19305	1090758..1091435	+	678	WP_152432574.1	iron-containing redox enzyme family protein	-
FIV01_RS19310	1091389..1091694	+	306	WP_152432575.1	2Fe-2S iron-sulfur cluster binding domain-containing protein	-
FIV01_RS19315	1092332..1092592	+	261	WP_152432576.1	DUF5062 family protein	-
FIV01_RS19320	1093316..1093612	-	297	WP_152432577.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FIV01_RS19325	1093619..1093861	-	243	WP_000557295.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FIV01_RS19330	1094035..1094407	-	373	Protein_942	transposase	-
FIV01_RS19335	1094771..1095424	+	654	WP_152432789.1	AzlC family ABC transporter permease	-
FIV01_RS19340	1095414..1095746	+	333	WP_152432578.1	AzlD domain-containing protein	-
FIV01_RS19345	1096133..1096624	+	492	WP_152432579.1	GNAT family N-acetyltransferase	-
FIV01_RS19350	1096697..1097608	-	912	WP_172971882.1	substrate-binding domain-containing protein	-
FIV01_RS19355	1097862..1098324	+	463	Protein_947	DoxX family protein	-
FIV01_RS19360	1098363..1098719	-	357	WP_152432581.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	katB / vscS2 / vscN2 / vscC2 / vscR2 / vscU2 / vcrD2 / vipB/mglB	1..1317907	1317907

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-61)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11305.96 Da
• Isoelectric Point: 9.6269

>T141737 WP_152432577.1 NZ_CP045351:c1093612-1093316 [Vibrio aquimaris]
MQKNKYKLSKLAQTHLQKIKNYTVNNFSEMQWRSYKDTLLTGFQMLADNPAVGRNCDEIYPSGFYFPVGKHTAYFTKEDG
FILVVAVLGQSQLPQNHL

Nucleotide

• Length: 297 bp

>T141737 NZ_CP060075:2473955-2475277 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9002.17 Da
• Isoelectric Point: 4.7914

>AT141737 WP_000557295.1 NZ_CP045351:c1093861-1093619 [Vibrio aquimaris]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDAVVVMSIKDYEELEAMKTDYLRHCFESAKQDLAQGNVVDGEDFLNAL

Nucleotide

• Length: 243 bp

>AT141737 NZ_CP060075:2473689-2473955 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAAATCTGGAGTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A151KU25