Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 704140..705968 Replicon chromosome
Accession NZ_CP045350
Organism Vibrio aquimaris strain THAF100

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag FIV01_RS03250 Protein ID WP_172971806.1
Coordinates 704607..705968 (-) Length 454 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag FIV01_RS03245 Protein ID WP_152429706.1
Coordinates 704140..704622 (-) Length 161 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FIV01_RS03225 699380..701761 + 2382 WP_152429702.1 S8 family serine peptidase -
FIV01_RS03230 701771..702112 + 342 WP_152429703.1 ATPase -
FIV01_RS03235 702331..702660 + 330 WP_152429704.1 helix-turn-helix transcriptional regulator -
FIV01_RS03240 702657..703919 + 1263 WP_152429705.1 type II toxin-antitoxin system HipA family toxin -
FIV01_RS03245 704140..704622 - 483 WP_152429706.1 helix-turn-helix domain-containing protein Antitoxin
FIV01_RS03250 704607..705968 - 1362 WP_172971806.1 type II toxin-antitoxin system HipA family toxin Toxin
FIV01_RS03255 706388..708721 + 2334 WP_152429708.1 type I restriction-modification system subunit M -
FIV01_RS03260 708721..710130 + 1410 WP_152429709.1 restriction endonuclease subunit S -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-392)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-143)


Sequences

Toxin        


Download         Length: 454 a.a.        Molecular weight: 51565.42 Da        Isoelectric Point: 4.9260

>T141733 WP_172971806.1 NZ_CP045350:c705968-704607 [Vibrio aquimaris]
MEELTVQAFIKGEWIDIGIISFPKSRQHNFRVTELNYLSDYALEHHDKDDFHAVSLNYPISFFFDDMGKPGWLTFLDDIM
PSGASRRYWVKHLDIEDLSSDEQDYVLLKFGTMSPIGNLRIKDSLPERYEVADNLYFSVDDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLILRCGFDHSSSSEKIWIDPYQDDNSNHDLHYLVKYPRGSRSTIDCNILRAEFYFYHELTEMGVETIS
TDGMRLEEGLNYPSLWLPRFDVQVIEQQIERVGMESVYSILNKGAGVTLDHETTIRTLIEKITESNMVKHQGYRFDTQAF
VIEWVKRDLLNILFGNSDNHGRNTSFLKGDGVIKLAPIYDFAPMKADPEGIPRTTKWKAPLEVGGTYDFVKITDTLSDLV
PKEVLLQELKVTASKCIDLKQRLALRGVPEQILEMPATGLNHISEKLTKWGLL

Download         Length: 1362 bp

>T141733 NZ_CP060075:971269-971676 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 161 a.a.        Molecular weight: 17736.32 Da        Isoelectric Point: 10.8587

>AT141733 WP_152429706.1 NZ_CP045350:c704622-704140 [Vibrio aquimaris]
MGATMNKPNNKESVQDTVARLRANRNQHQPKTGTNAIHSTKERSQLYAPTRSKASKNAKAVSAAERKTEANKIIKHLLLG
ELTQGQALKSLRINILGLKQDVFARLVDVSRKTLSDIENDRGSYNTEILNKVFKPFGLKVGLLPSSPNTLKSLLMDGEDW

Download         Length: 483 bp

>AT141733 NZ_CP060075:971022-971288 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTATGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References