Detailed information of TA system TA141732

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 3830552..3831749
• Replicon: chromosome
• Accession: NZ_CP045349
• Organism: Pseudomonas sp. THAF187a

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: FIV02_RS17765
• Protein ID: WP_152489373.1
• Coordinates: 3830552..3831304 (-)
• Length: 251 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A5P9CAU4
• Locus tag: FIV02_RS17770
• Protein ID: WP_037049292.1
• Coordinates: 3831378..3831749 (-)
• Length: 124 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FIV02_RS17740	3826458..3827375	+	918	WP_152489370.1	alpha/beta fold hydrolase	-
FIV02_RS17745	3827372..3828262	+	891	WP_152489371.1	metal-dependent hydrolase	-
FIV02_RS17750	3828320..3829681	-	1362	WP_167494366.1	DNA recombination protein RmuC	-
FIV02_RS17755	3829862..3830113	-	252	WP_037049286.1	hypothetical protein	-
FIV02_RS17760	3830112..3830408	+	297	WP_152489372.1	hypothetical protein	-
FIV02_RS17765	3830552..3831304	-	753	WP_152489373.1	RES family NAD+ phosphorylase	Toxin
FIV02_RS17770	3831378..3831749	-	372	WP_037049292.1	XRE family transcriptional regulator	Antitoxin
FIV02_RS17775	3831884..3834445	+	2562	WP_152489374.1	YdbH domain-containing protein	-
FIV02_RS17780	3834450..3834641	+	192	WP_037049298.1	YnbE family lipoprotein	-
FIV02_RS17785	3834734..3835072	+	339	WP_037049301.1	YdbL family protein	-
FIV02_RS17790	3835144..3835470	-	327	WP_037049304.1	Grx4 family monothiol glutaredoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (62-207)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (72-121)

Sequences

Toxin

Protein

• Length: 251 a.a.
• Molecular weight: 28179.17 Da
• Isoelectric Point: 8.2660

>T141732 WP_152489373.1 NZ_CP045349:c3831304-3830552 [Pseudomonas sp. THAF187a]
MDIWQQCAGERQVRPLRGKLLRMVESQAQVATSQLVDNLAEQALLEDLLENSKPPLPEAAEPLHYLLKTPFRYPPLRWGS
RFGTVHEPSLFYAAQHLQTAMAEAAYYRFVLWNGMLSPPPSGRILSEHSTFEARYRVERGIQLQLPPFDAHAAQLAHPSD
YSVAQRLGAAMRAADIQAFEYRSARCPAGGSNVALYVPQAFAEKRPRNLTAWLCETTGDYVAFKPAQVPGQPRLFRWEQF
LVQGQLPHPA

Nucleotide

• Length: 753 bp

>T141732 NZ_CP060075:c844549-844172 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGGTTGCTGGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCAGGGCAACCGGCCTGATGACCCGCGA
TAACTACAGAACGGTAAATAACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin

Protein

• Length: 124 a.a.
• Molecular weight: 13598.76 Da
• Isoelectric Point: 10.6604

>AT141732 WP_037049292.1 NZ_CP045349:c3831749-3831378 [Pseudomonas sp. THAF187a]
MSALIRSQPDADAVLAKALLNTREQLGLTQQELADIVGVHRSAISRWGEQGGLRPQSKTGELALLLIRAYRALFALFGGN
LQDMRHFLRTENRHLAGVPLQQMGQVQGLVRVVEYLDAIRGKV

Nucleotide

• Length: 372 bp

>AT141732 NZ_CP060075:c844965-844639 [Escherichia coli]
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCGCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCTTCGGCTCCTGTGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAA
AAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A5P9CAU4