Detailed information of TA system TA141728

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-Phd
• Location: 67675..68321
• Replicon: plasmid pTHAF187b_b
• Accession: NZ_CP045346
• Organism: Labrenzia sp. THAF187b

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FIV03_RS30635
• Protein ID: WP_062492135.1
• Coordinates: 67675..68082 (-)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FIV03_RS30640
• Protein ID: WP_082809967.1
• Coordinates: 68079..68321 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FIV03_RS30615	64249..64536	-	288	WP_062492139.1	hypothetical protein	-
FIV03_RS30620	64841..65185	-	345	WP_062492226.1	DUF736 family protein	-
FIV03_RS30625	65461..67179	-	1719	WP_152508058.1	Fic family protein	-
FIV03_RS30630	67244..67450	-	207	WP_062492137.1	antitoxin VbhA family protein	-
FIV03_RS30635	67675..68082	-	408	WP_062492135.1	type II toxin-antitoxin system VapC family toxin	Toxin
FIV03_RS30640	68079..68321	-	243	WP_082809967.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FIV03_RS30645	68436..69692	-	1257	WP_062492133.1	replication protein C	-
FIV03_RS30650	69916..70917	-	1002	WP_152508057.1	plasmid partitioning protein RepB	-
FIV03_RS30655	70921..72114	-	1194	WP_088665297.1	plasmid partitioning protein RepA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..120832	120832

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-118)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-50)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 15120.26 Da
• Isoelectric Point: 5.2058

>T141728 WP_062492135.1 NZ_CP045346:c68082-67675 [Labrenzia sp. THAF187b]
MIYVLDTNVITAARRAERAPKVAAWLSDKPEETLYVSVVTLGEIERGIRLQERRNMDFAKHLRQWLDRTVSMFGDRLLEF
TASDALCWGELSARIGHNGADLMIAAQALTRNGWVVTGNASDFEPTGVQLVDPFV

Nucleotide

• Length: 408 bp

>T141728 NZ_CP060075:c50223-49882 [Escherichia coli]
ATGAACACCTCTCCTGCAACAAATCAGCGGGTAGCGAAGCCATGCCCGTCGCCTGTGGCCGTCTGGCAGATGTTACTGAC
CCGTCTACTTGCACAACACTATGGCCTGGCCCTGAGTGACACGCCATTCTGCGATGAAACAGTCATTCAGGAACATATCA
ACGCAGGCGTTACTCTTGCCGATGCCGTGAACTTTCTGGTGGAAAAATACGAACTCGTTCGCATCGATCGCAAAGGATTT
AGCTGGCAGGAACAATCGCCTTATCTGCGGGCTGTAGACATTTTGCGGGCGCGACAGGCAATGGGGTTGTTACGACAAGG
CCATAATCTTTCGACACGCTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9002.25 Da
• Isoelectric Point: 10.4416

>AT141728 WP_082809967.1 NZ_CP045346:c68321-68079 [Labrenzia sp. THAF187b]
MISLQDAKNRFSAVVEAAMAGRPQEVSRRGKPAVVVISSEEYRRLLREAKGRRESFADHVLSFPGEGIERSKVTPRDVEF

Nucleotide

• Length: 243 bp

>AT141728 NZ_CP060075:c50603-50259 [Escherichia coli]
ATGAAAAAAGACACAGCCAATGAAGTAGTGGATACGCTGCGATGGGGACTGAAATGCGACATCACACCACATTTCGGGGC
CCGTCTGGTGCAGGAAGGCAACCGCCTGCATTACCTCGCCGATCGGGCCAGCATAATCGGTCCGTTCAGCAAAGCTGATT
TACGCCATCTCAACCAGGCTTTCCCCTTGTTGATGAAGCAAATGGAGCTCATGCTCACCAGCGGAGAACTTAATTCCCGG
CACCAGCACTGCGTCACGCTGTATGCGAAAGGATTAACCTGTGAAGCCGATACGCTCGGCTCTTGTGGCTACGTCTATAT
CGCCATTTACCCCACTCAACGCTGA