Detailed information of TA system TA141727

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 46244..46818
• Replicon: plasmid pTHAF187b_a
• Accession: NZ_CP045345
• Organism: Labrenzia sp. THAF187b

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FIV03_RS28035
• Protein ID: WP_081713154.1
• Coordinates: 46244..46558 (-)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FIV03_RS28040
• Protein ID: WP_152512140.1
• Coordinates: 46588..46818 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FIV03_RS28010	41268..42134	-	867	WP_173014028.1	ABC transporter permease	-
FIV03_RS28015	42131..43072	-	942	WP_152512138.1	ABC transporter permease	-
FIV03_RS28020	43219..44784	-	1566	WP_173014035.1	ABC transporter substrate-binding protein	-
FIV03_RS28025	45099..45695	+	597	WP_051990042.1	XRE family transcriptional regulator	-
FIV03_RS28035	46244..46558	-	315	WP_081713154.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FIV03_RS28040	46588..46818	-	231	WP_152512140.1	ribbon-helix-helix protein, CopG family	Antitoxin
FIV03_RS28045	46988..47516	+	529	Protein_46	recombinase family protein	-
FIV03_RS28050	47628..48473	-	846	WP_152512141.1	alkaline phosphatase family protein	-
FIV03_RS28055	48470..49063	-	594	WP_152512142.1	HD domain-containing protein	-
FIV03_RS28060	49060..50211	-	1152	WP_152512143.1	TauD/TfdA family dioxygenase	-
FIV03_RS28065	50310..51167	+	858	WP_152512144.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	entE	1..538462	538462
	-	flank	IS/Tn	-	-	47049..47330	281

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-95)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 11743.50 Da
• Isoelectric Point: 7.9955

>T141727 WP_081713154.1 NZ_CP045345:c46558-46244 [Labrenzia sp. THAF187b]
VPRVIVTEGAALGLERCRRFLAVKSSEAGRRAGQAIERQFLLLETPPDFGRPNPDLPELRELLITFGDSGYVSLYRYEPA
VDVLYVLAFRHQKKQATEERVSVV

Nucleotide

• Length: 315 bp

>T141727 NZ_CP060073:c4202340-4202167 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8951.28 Da
• Isoelectric Point: 9.8241

>AT141727 WP_152512140.1 NZ_CP045345:c46818-46588 [Labrenzia sp. THAF187b]
MATSLKIDDVLKGRVQYLAVKRRRSPHWIMLEAIRQFFEREEACECLKQEALASRSTYQETGRHLTGQEVRTRLNT

Nucleotide

• Length: 231 bp

>AT141727 NZ_CP060073:c4202664-4202368 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG