Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 201801..202329 Replicon plasmid pTHAF190c_b
Accession NZ_CP045340
Organism Vibrio sp. THAF190c

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag FIV04_RS23660 Protein ID WP_152470869.1
Coordinates 201801..202091 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR02
Locus tag FIV04_RS23665 Protein ID WP_005377003.1
Coordinates 202081..202329 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FIV04_RS23625 197407..197868 + 462 WP_152470864.1 hypothetical protein -
FIV04_RS27035 197840..198175 + 336 WP_172974318.1 hypothetical protein -
FIV04_RS23635 198314..198664 + 351 WP_152470865.1 cupin domain-containing protein -
FIV04_RS23640 198812..199237 + 426 WP_152470866.1 hypothetical protein -
FIV04_RS23645 199799..200824 - 1026 Protein_194 IS110 family transposase -
FIV04_RS23650 200918..201379 + 462 WP_152470867.1 hypothetical protein -
FIV04_RS23655 201425..201673 + 249 WP_152470868.1 hypothetical protein -
FIV04_RS23660 201801..202091 - 291 WP_152470869.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FIV04_RS23665 202081..202329 - 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FIV04_RS23675 202525..202842 + 318 WP_134837121.1 heavy metal-binding domain-containing protein -
FIV04_RS23680 202839..202994 + 156 WP_152471139.1 DUF3265 domain-containing protein -
FIV04_RS23685 202941..203840 - 900 WP_152470870.1 LysR family transcriptional regulator -
FIV04_RS23690 203994..204491 + 498 WP_152470871.1 nuclear transport factor 2 family protein -
FIV04_RS23695 204502..204777 + 276 WP_152470872.1 ankyrin repeat domain-containing protein -
FIV04_RS23700 204848..206395 + 1548 WP_152470873.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - katB 1..518670 518670
- flank IS/Tn - - 200054..200824 770


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-75)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11279.28 Da        Isoelectric Point: 10.5932

>T141723 WP_152470869.1 NZ_CP045340:c202091-201801 [Vibrio sp. THAF190c]
MTYKLDFKKSALKEWKKLGSTMQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Download         Length: 291 bp

>T141723 NZ_CP060073:2628102-2628209 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9079.37 Da        Isoelectric Point: 3.9610

>AT141723 WP_005377003.1 NZ_CP045340:c202329-202081 [Vibrio sp. THAF190c]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT141723 NZ_CP060073:c2628055-2627989 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR02

References