Detailed information of TA system TA141722

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 110983..111557
• Replicon: plasmid pTHAF191a_b
• Accession: NZ_CP045335
• Organism: Labrenzia sp. THAF191a

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FIV05_RS28930
• Protein ID: WP_081713154.1
• Coordinates: 111243..111557 (+)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FIV05_RS28925
• Protein ID: WP_152512140.1
• Coordinates: 110983..111213 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FIV05_RS28900	106634..107491	-	858	WP_152512144.1	LysR family transcriptional regulator	-
FIV05_RS28905	107590..108741	+	1152	WP_152512143.1	TauD/TfdA family dioxygenase	-
FIV05_RS28910	108738..109331	+	594	WP_152512142.1	HD domain-containing protein	-
FIV05_RS28915	109328..110173	+	846	WP_152512141.1	alkaline phosphatase family protein	-
FIV05_RS28920	110285..110813	-	529	Protein_102	recombinase family protein	-
FIV05_RS28925	110983..111213	+	231	WP_152512140.1	ribbon-helix-helix protein, CopG family	Antitoxin
FIV05_RS28930	111243..111557	+	315	WP_081713154.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FIV05_RS28940	112106..112702	-	597	WP_051990042.1	XRE family transcriptional regulator	-
FIV05_RS28945	113017..114582	+	1566	WP_173014035.1	ABC transporter substrate-binding protein	-
FIV05_RS28950	114729..115670	+	942	WP_152512138.1	ABC transporter permease	-
FIV05_RS28955	115667..116533	+	867	WP_173014028.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	entE	1..539584	539584
	-	flank	IS/Tn	-	-	110471..110752	281

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-95)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 11743.50 Da
• Isoelectric Point: 7.9955

>T141722 WP_081713154.1 NZ_CP045335:111243-111557 [Labrenzia sp. THAF191a]
VPRVIVTEGAALGLERCRRFLAVKSSEAGRRAGQAIERQFLLLETPPDFGRPNPDLPELRELLITFGDSGYVSLYRYEPA
VDVLYVLAFRHQKKQATEERVSVV

Nucleotide

• Length: 315 bp

>T141722 NZ_CP060073:2627567-2627674 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8951.28 Da
• Isoelectric Point: 9.8241

>AT141722 WP_152512140.1 NZ_CP045335:110983-111213 [Labrenzia sp. THAF191a]
MATSLKIDDVLKGRVQYLAVKRRRSPHWIMLEAIRQFFEREEACECLKQEALASRSTYQETGRHLTGQEVRTRLNT

Nucleotide

• Length: 231 bp

>AT141722 NZ_CP060073:c2627520-2627454 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT