Detailed information of TA system TA141721

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-Phd
• Location: 15080..15726
• Replicon: plasmid pTHAF191a_a
• Accession: NZ_CP045334
• Organism: Labrenzia sp. THAF191a

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FIV05_RS27910
• Protein ID: WP_062492135.1
• Coordinates: 15319..15726 (+)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FIV05_RS27905
• Protein ID: WP_082809967.1
• Coordinates: 15080..15322 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FIV05_RS27890	11287..12480	+	1194	WP_088665297.1	plasmid partitioning protein RepA	-
FIV05_RS27895	12484..13485	+	1002	WP_152508057.1	plasmid partitioning protein RepB	-
FIV05_RS27900	13709..14965	+	1257	WP_062492133.1	replication protein C	-
FIV05_RS27905	15080..15322	+	243	WP_082809967.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FIV05_RS27910	15319..15726	+	408	WP_062492135.1	type II toxin-antitoxin system VapC family toxin	Toxin
FIV05_RS27915	15951..16157	+	207	WP_062492137.1	antitoxin VbhA family protein	-
FIV05_RS27920	16222..17940	+	1719	WP_152508058.1	Fic family protein	-
FIV05_RS27925	18216..18560	+	345	WP_062492226.1	DUF736 family protein	-
FIV05_RS27930	18865..19152	+	288	WP_062492139.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..120832	120832

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-118)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-50)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 15120.26 Da
• Isoelectric Point: 5.2058

>T141721 WP_062492135.1 NZ_CP045334:15319-15726 [Labrenzia sp. THAF191a]
MIYVLDTNVITAARRAERAPKVAAWLSDKPEETLYVSVVTLGEIERGIRLQERRNMDFAKHLRQWLDRTVSMFGDRLLEF
TASDALCWGELSARIGHNGADLMIAAQALTRNGWVVTGNASDFEPTGVQLVDPFV

Nucleotide

• Length: 408 bp

>T141721 NZ_CP060073:c2415320-2415144 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9002.25 Da
• Isoelectric Point: 10.4416

>AT141721 WP_082809967.1 NZ_CP045334:15080-15322 [Labrenzia sp. THAF191a]
MISLQDAKNRFSAVVEAAMAGRPQEVSRRGKPAVVVISSEEYRRLLREAKGRRESFADHVLSFPGEGIERSKVTPRDVEF

Nucleotide

• Length: 243 bp

>AT141721 NZ_CP060073:c2415098-2414682 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA