Detailed information of TA system TA141719

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-Phd
• Location: 67675..68321
• Replicon: plasmid pTHAF191b_b
• Accession: NZ_CP045330
• Organism: Labrenzia sp. THAF191b

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FIV06_RS30640
• Protein ID: WP_062492135.1
• Coordinates: 67675..68082 (-)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FIV06_RS30645
• Protein ID: WP_082809967.1
• Coordinates: 68079..68321 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FIV06_RS30620	64249..64536	-	288	WP_062492139.1	hypothetical protein	-
FIV06_RS30625	64841..65185	-	345	WP_062492226.1	DUF736 family protein	-
FIV06_RS30630	65461..67179	-	1719	WP_152508058.1	Fic family protein	-
FIV06_RS30635	67244..67450	-	207	WP_062492137.1	antitoxin VbhA family protein	-
FIV06_RS30640	67675..68082	-	408	WP_062492135.1	type II toxin-antitoxin system VapC family toxin	Toxin
FIV06_RS30645	68079..68321	-	243	WP_082809967.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FIV06_RS30650	68436..69692	-	1257	WP_062492133.1	replication protein C	-
FIV06_RS30655	69916..70917	-	1002	WP_152508057.1	plasmid partitioning protein RepB	-
FIV06_RS30660	70921..72114	-	1194	WP_088665297.1	plasmid partitioning protein RepA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..120832	120832

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-118)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-50)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 15120.26 Da
• Isoelectric Point: 5.2058

>T141719 WP_062492135.1 NZ_CP045330:c68082-67675 [Labrenzia sp. THAF191b]
MIYVLDTNVITAARRAERAPKVAAWLSDKPEETLYVSVVTLGEIERGIRLQERRNMDFAKHLRQWLDRTVSMFGDRLLEF
TASDALCWGELSARIGHNGADLMIAAQALTRNGWVVTGNASDFEPTGVQLVDPFV

Nucleotide

• Length: 408 bp

>T141719 NZ_CP060073:2231133-2231420 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9002.25 Da
• Isoelectric Point: 10.4416

>AT141719 WP_082809967.1 NZ_CP045330:c68321-68079 [Labrenzia sp. THAF191b]
MISLQDAKNRFSAVVEAAMAGRPQEVSRRGKPAVVVISSEEYRRLLREAKGRRESFADHVLSFPGEGIERSKVTPRDVEF

Nucleotide

• Length: 243 bp

>AT141719 NZ_CP060073:2230894-2231133 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA