Detailed information of TA system TA141716

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 4167972..4168519
• Replicon: chromosome
• Accession: NZ_CP045324
• Organism: Marinobacter sp. THAF197a

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A5P9ER54
• Locus tag: FIV08_RS19175
• Protein ID: WP_072675918.1
• Coordinates: 4167972..4168274 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U7FV42
• Locus tag: FIV08_RS19180
• Protein ID: WP_022990189.1
• Coordinates: 4168262..4168519 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FIV08_RS19150	4164080..4165849	-	1770	WP_152439483.1	DUF4394 domain-containing protein	-
FIV08_RS19155	4166037..4166777	-	741	WP_152439484.1	transporter substrate-binding domain-containing protein	-
FIV08_RS19160	4166889..4167290	-	402	WP_152439485.1	GFA family protein	-
FIV08_RS19165	4167323..4167586	-	264	WP_152439486.1	Txe/YoeB family addiction module toxin	-
FIV08_RS19170	4167583..4167825	-	243	WP_152439487.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
FIV08_RS19175	4167972..4168274	-	303	WP_072675918.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FIV08_RS19180	4168262..4168519	-	258	WP_022990189.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FIV08_RS19185	4168694..4169341	-	648	WP_152439488.1	hypothetical protein	-
FIV08_RS19190	4169441..4169737	-	297	WP_152439647.1	hypothetical protein	-
FIV08_RS19195	4169814..4170428	-	615	WP_152439489.1	hypothetical protein	-
FIV08_RS19200	4170535..4170885	-	351	WP_152439490.1	hypothetical protein	-
FIV08_RS19205	4171090..4171599	-	510	WP_152439491.1	hypothetical protein	-
FIV08_RS19210	4171738..4172007	-	270	WP_152439492.1	hypothetical protein	-
FIV08_RS19215	4172146..4172634	-	489	WP_152439493.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11632.35 Da
• Isoelectric Point: 4.3363

>T141716 WP_072675918.1 NZ_CP045324:c4168274-4167972 [Marinobacter sp. THAF197a]
MAEVIWTEPALQELDAIAEYIALDNPAAASYLVQEVFDKTERLENFPQSGRIPPELPNSVYREVVVPPCRIFYREDEKRV
LILYVMREERQLRAFMLGSS

Nucleotide

• Length: 303 bp

>T141716 NZ_CP060073:880971-881378 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9887.41 Da
• Isoelectric Point: 8.5042

>AT141716 WP_022990189.1 NZ_CP045324:c4168519-4168262 [Marinobacter sp. THAF197a]
MKVELVTNLKRQATKILADLHLSKEPVLITEHGQPSAYLVDVQDYEFMQRRLELLEGLSRGERAVLEGRTYSQSEAREKM
SKWLK

Nucleotide

• Length: 258 bp

>AT141716 NZ_CP060073:880724-880990 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCAGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: A0A5P9ER54

Antitoxin

• AlphaFold DB: A0A1I1I6C4