Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 4167972..4168519 Replicon chromosome
Accession NZ_CP045324
Organism Marinobacter sp. THAF197a

Toxin (Protein)


Gene name relE Uniprot ID A0A5P9ER54
Locus tag FIV08_RS19175 Protein ID WP_072675918.1
Coordinates 4167972..4168274 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U7FV42
Locus tag FIV08_RS19180 Protein ID WP_022990189.1
Coordinates 4168262..4168519 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FIV08_RS19150 4164080..4165849 - 1770 WP_152439483.1 DUF4394 domain-containing protein -
FIV08_RS19155 4166037..4166777 - 741 WP_152439484.1 transporter substrate-binding domain-containing protein -
FIV08_RS19160 4166889..4167290 - 402 WP_152439485.1 GFA family protein -
FIV08_RS19165 4167323..4167586 - 264 WP_152439486.1 Txe/YoeB family addiction module toxin -
FIV08_RS19170 4167583..4167825 - 243 WP_152439487.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FIV08_RS19175 4167972..4168274 - 303 WP_072675918.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FIV08_RS19180 4168262..4168519 - 258 WP_022990189.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FIV08_RS19185 4168694..4169341 - 648 WP_152439488.1 hypothetical protein -
FIV08_RS19190 4169441..4169737 - 297 WP_152439647.1 hypothetical protein -
FIV08_RS19195 4169814..4170428 - 615 WP_152439489.1 hypothetical protein -
FIV08_RS19200 4170535..4170885 - 351 WP_152439490.1 hypothetical protein -
FIV08_RS19205 4171090..4171599 - 510 WP_152439491.1 hypothetical protein -
FIV08_RS19210 4171738..4172007 - 270 WP_152439492.1 hypothetical protein -
FIV08_RS19215 4172146..4172634 - 489 WP_152439493.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11632.35 Da        Isoelectric Point: 4.3363

>T141716 WP_072675918.1 NZ_CP045324:c4168274-4167972 [Marinobacter sp. THAF197a]
MAEVIWTEPALQELDAIAEYIALDNPAAASYLVQEVFDKTERLENFPQSGRIPPELPNSVYREVVVPPCRIFYREDEKRV
LILYVMREERQLRAFMLGSS

Download         Length: 303 bp

>T141716 NZ_CP060073:880971-881378 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9887.41 Da        Isoelectric Point: 8.5042

>AT141716 WP_022990189.1 NZ_CP045324:c4168519-4168262 [Marinobacter sp. THAF197a]
MKVELVTNLKRQATKILADLHLSKEPVLITEHGQPSAYLVDVQDYEFMQRRLELLEGLSRGERAVLEGRTYSQSEAREKM
SKWLK

Download         Length: 258 bp

>AT141716 NZ_CP060073:880724-880990 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCAGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5P9ER54

Antitoxin

Source ID Structure
AlphaFold DB A0A1I1I6C4

References