Detailed information of TA system TA141714

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /BrnT(toxin)
• Location: 2419053..2419575
• Replicon: chromosome
• Accession: NZ_CP045324
• Organism: Marinobacter sp. THAF197a

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: FIV08_RS11225
• Protein ID: WP_152438361.1
• Coordinates: 2419312..2419575 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A7Z0LM09
• Locus tag: FIV08_RS11220
• Protein ID: WP_074396173.1
• Coordinates: 2419053..2419322 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FIV08_RS11190	2414415..2414747	-	333	WP_152438355.1	hypothetical protein	-
FIV08_RS11195	2414824..2415276	-	453	WP_152438356.1	hypothetical protein	-
FIV08_RS11200	2415429..2416232	-	804	WP_152438357.1	IS21-like element helper ATPase IstB	-
FIV08_RS11205	2416229..2417413	-	1185	WP_152438358.1	IS21 family transposase	-
FIV08_RS11210	2417885..2418331	-	447	WP_152438359.1	hypothetical protein	-
FIV08_RS11215	2418440..2419018	-	579	WP_152438360.1	hypothetical protein	-
FIV08_RS11220	2419053..2419322	-	270	WP_074396173.1	CopG family transcriptional regulator	Antitoxin
FIV08_RS11225	2419312..2419575	-	264	WP_152438361.1	BrnT family toxin	Toxin
FIV08_RS11230	2419722..2420369	-	648	WP_152438362.1	hypothetical protein	-
FIV08_RS11235	2420469..2420765	-	297	WP_152439647.1	hypothetical protein	-
FIV08_RS11240	2420892..2421305	-	414	WP_152438363.1	GNAT family N-acetyltransferase	-
FIV08_RS11245	2421431..2421763	-	333	WP_152438364.1	hypothetical protein	-
FIV08_RS11250	2421860..2422483	-	624	WP_152438365.1	SagB/ThcOx family dehydrogenase	-
FIV08_RS11255	2422558..2423187	-	630	WP_152438366.1	hypothetical protein	-
FIV08_RS11260	2423298..2423717	-	420	WP_152438367.1	hypothetical protein	-
FIV08_RS19720	2423831..2423986	-	156	WP_172972271.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2408229..2432055	23826
	-	flank	IS/Tn	-	-	2415429..2416232	803
	-	inside	Integron	-	-	2411435..2436287	24852

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (6-81)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10310.73 Da
• Isoelectric Point: 7.2036

>T141714 WP_152438361.1 NZ_CP045324:c2419575-2419312 [Marinobacter sp. THAF197a]
MDEFEFDDAKSQANLDKHGIDFVAAQRLWKDPYLLEIRAKSEDEPRFLLVGKIGEKHWSAVVTYRDARIRLISVRRSRKK
EVELYES

Nucleotide

• Length: 264 bp

>T141714 NZ_CP060073:653500-653814 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10021.22 Da
• Isoelectric Point: 4.8838

>AT141714 WP_074396173.1 NZ_CP045324:c2419322-2419053 [Marinobacter sp. THAF197a]
MKAKDFDKKFEEGQEDIVDDLDLSSARRVNQEQKRINVDFPAWVVESLDREAARIGVTRQSIIKVWLVERLQAESANKPL
NGDAAGGAH

Nucleotide

• Length: 270 bp

>AT141714 NZ_CP060073:653811-654227 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Structures

Antitoxin

• AlphaFold DB: A0A7Z0LM09