Detailed information of TA system TA141712

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 2183529..2184685
• Replicon: chromosome
• Accession: NZ_CP045324
• Organism: Marinobacter sp. THAF197a

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: FIV08_RS10120
• Protein ID: WP_152438237.1
• Coordinates: 2183891..2184685 (+)
• Length: 265 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: FIV08_RS10115
• Protein ID: WP_152438236.1
• Coordinates: 2183529..2183894 (+)
• Length: 122 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FIV08_RS10100	2178688..2180292	+	1605	WP_152438233.1	FAD-binding oxidoreductase	-
FIV08_RS10105	2180300..2181886	+	1587	WP_152438234.1	glycerol-3-phosphate dehydrogenase/oxidase	-
FIV08_RS10110	2181892..2183451	+	1560	WP_152438235.1	FGGY-family carbohydrate kinase	-
FIV08_RS10115	2183529..2183894	+	366	WP_152438236.1	MbcA/ParS/Xre antitoxin family protein	Antitoxin
FIV08_RS10120	2183891..2184685	+	795	WP_152438237.1	RES family NAD+ phosphorylase	Toxin
FIV08_RS10125	2184663..2186069	-	1407	WP_152439637.1	efflux transporter outer membrane subunit	-
FIV08_RS10130	2186080..2188020	-	1941	WP_152438238.1	MacB family efflux pump subunit	-
FIV08_RS10135	2188017..2189168	-	1152	WP_152438239.1	efflux RND transporter periplasmic adaptor subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (59-219)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (12-66)

Sequences

Toxin

Protein

• Length: 265 a.a.
• Molecular weight: 29692.80 Da
• Isoelectric Point: 9.8431

>T141712 WP_152438237.1 NZ_CP045324:2183891-2184685 [Marinobacter sp. THAF197a]
MNYRERIKGTLGSLQGQLFRVVESQEDIATTRIVDNMQEQARLEQLLDASKPRIPEQASKLHYLLATPFRYPPLKYGSRF
GRSFEPSLFYGAMSIPTALAETAFYRFVFTSHVSEPFKRPLTTLHTVFTARFRSSRGVRLQATEWQDLQKTLTDPVSYRE
SQALGSDLRHCGAEAFQFLSARALQAGLYQLPWQTGSGMDGLNVALFSPRALRDTAPRSYHKLIVATSDQQVSMSLTLAD
GSKQVHNFGREAFLVEGVIPQPAL

Nucleotide

• Length: 795 bp

>T141712 NZ_CP060073:190679-190786 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Protein

• Length: 122 a.a.
• Molecular weight: 13143.93 Da
• Isoelectric Point: 8.5040

>AT141712 WP_152438236.1 NZ_CP045324:2183529-2183894 [Marinobacter sp. THAF197a]
MNEPATLAPQTSDKALLAKALLNSAKAFGLSQAEAAAVVGRNRSGLTRDGIDPDSKSGELALLFVRLYRSVYALTGGDNQ
AMAHWLNTPNHYFEGTPRDMIQSTEGLVRVIHYLDAMRGRI

Nucleotide

• Length: 366 bp

>AT141712 NZ_CP060073:c190631-190565 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT