Detailed information of TA system TA141711

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 10219..10780
• Replicon: plasmid pTHAF197b_c
• Accession: NZ_CP045321
• Organism: Roseivivax sp. THAF197b

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A917AH87
• Locus tag: FIV09_RS19745
• Protein ID: WP_071974127.1
• Coordinates: 10505..10780 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1N7QLX2
• Locus tag: FIV09_RS19740
• Protein ID: WP_044353023.1
• Coordinates: 10219..10518 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FIV09_RS19715	5254..6192	+	939	WP_090525075.1	DUF1738 domain-containing protein	-
FIV09_RS19720	6263..6652	+	390	WP_090525076.1	DUF3768 domain-containing protein	-
FIV09_RS19725	6809..8791	+	1983	WP_152453328.1	ParB/RepB/Spo0J family partition protein	-
FIV09_RS19730	8865..9458	+	594	WP_152453330.1	regulator	-
FIV09_RS19735	9458..10114	+	657	WP_090525082.1	hypothetical protein	-
FIV09_RS19740	10219..10518	+	300	WP_044353023.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
FIV09_RS19745	10505..10780	+	276	WP_071974127.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
FIV09_RS19750	10888..15150	+	4263	WP_152453332.1	strawberry notch family protein	-
FIV09_RS19755	15271..15657	+	387	WP_090525086.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..84228	84228

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-54)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10388.92 Da
• Isoelectric Point: 4.5837

>T141711 WP_071974127.1 NZ_CP045321:10505-10780 [Roseivivax sp. THAF197b]
MPNLEWKATAIADLLAIIDYISDDNPDAAQVLKDEIEHKTSLLPERPQMYRAGRVDGTREMVVRPNYIVVYAESPEMVTI
LRVLHAAQQWP

Nucleotide

• Length: 276 bp

>T141711 NZ_CP060070:c1639-1373 [Escherichia coli]
TTGGTCTGGACGATTAACTATTCCGACCGGGCGCTCAAATCGTTACGCAAGATGGACAAACAGAACGCACGACGGATTGT
GGATTTTATGGATTTACGCATTGCAGTTGCTGCCGATCCTCGCCAGTCAGGGAAGCCGCTCAAAGGTGAGCTGGGCGAGT
TCTGGCGCTATCGGGTGGGAGATTATCGCATTCTGTGTGAGATCCGGGATGACGAGCTGGTTATCCTTGCCGCCACCATT
GGCCATCGCCGCGAAGTTTACGACTGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10462.91 Da
• Isoelectric Point: 5.6448

>AT141711 WP_044353023.1 NZ_CP045321:10219-10518 [Roseivivax sp. THAF197b]
MPAQTSMLHVRVDDQLKAQASDALAGVGLTLSDAVRILLTRVAAEGGLPAGLTADPDAYDAWFRAKVQEALDDPRPTTPH
AKAMQDAQALIDGKRLAKS

Nucleotide

• Length: 300 bp

>AT141711 NZ_CP060070:c1847-1623 [Escherichia coli]
ATGCTTGCTATCCGGTTATCTGATGAGATTGAGTCCCGTCTGGACTCGCTGGCGAAGCAAACCGGCAGAACAAAGACGTT
CTATGCGCGGGAAGCAATACTGGCGCATCTGGAAGACCTGGAAGATTATTATCTTTCAGCAGAAACTGCCGCACGCGTTC
GCCGTGGTGATGAAGCCGTGCATTCGTCTGAAGACGTGAGGAAGTCACTTGGTCTGGACGATTAA

Structures

Antitoxin

• AlphaFold DB: A0A1N7QLX2