Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4622651..4623267 Replicon chromosome
Accession NZ_CP045312
Organism Enterobacter hormaechei strain 14102KSN

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GC132_RS22165 Protein ID WP_080298797.1
Coordinates 4622651..4623022 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A9E7BIL4
Locus tag GC132_RS22170 Protein ID WP_023298920.1
Coordinates 4623025..4623267 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GC132_RS22150 4620151..4621053 + 903 WP_003861960.1 formate dehydrogenase subunit beta -
GC132_RS22155 4621050..4621685 + 636 WP_006808711.1 formate dehydrogenase cytochrome b556 subunit -
GC132_RS22160 4621682..4622611 + 930 WP_022649835.1 formate dehydrogenase accessory protein FdhE -
GC132_RS22165 4622651..4623022 - 372 WP_080298797.1 type II toxin-antitoxin system VapC family toxin Toxin
GC132_RS22170 4623025..4623267 - 243 WP_023298920.1 ribbon-helix-helix protein, CopG family Antitoxin
GC132_RS22175 4623467..4624387 + 921 WP_038416944.1 alpha/beta hydrolase -
GC132_RS22180 4624396..4625337 - 942 WP_022649838.1 fatty acid biosynthesis protein FabY -
GC132_RS22185 4625382..4625819 - 438 WP_015569909.1 D-tyrosyl-tRNA(Tyr) deacylase -
GC132_RS22190 4625816..4626697 - 882 WP_023298923.1 virulence factor BrkB family protein -
GC132_RS22195 4626691..4627290 - 600 WP_023315056.1 glucose-1-phosphatase -
GC132_RS22200 4627409..4628209 - 801 WP_038416949.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-114)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13612.66 Da        Isoelectric Point: 6.4865

>T141708 WP_080298797.1 NZ_CP045312:c4623022-4622651 [Enterobacter hormaechei]
MEHMAVYDTNILIDLFNNHVEAADAIDRTASHRAISLITWMEVMVGARRHGQEAKTAAVMGAFEIIDITREIAERSVLLR
EQHGMKLPDAIILATAQSRSCPLISRNTKDFSGIAGVVSPYHL

Download         Length: 372 bp

>T141708 NZ_CP060065:4124907-4125164 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9467.74 Da        Isoelectric Point: 4.3775

>AT141708 WP_023298920.1 NZ_CP045312:c4623267-4623025 [Enterobacter hormaechei]
MSLLADLTMGRILIDLSDDVIQRLDNLKQLRNRPRAELLREAIELYLDQQNSSVIREALGLWGNQQEDGLEYERKLREEW

Download         Length: 243 bp

>AT141708 NZ_CP060065:4125176-4125721 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTTAGCAAAGAAGCCGATTTAGTGACCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References