Detailed information of TA system TA141707

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3797727..3798384
• Replicon: chromosome
• Accession: NZ_CP045312
• Organism: Enterobacter hormaechei strain 14102KSN

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: GC132_RS18220
• Protein ID: WP_038416677.1
• Coordinates: 3797727..3798137 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: G8LDB7
• Locus tag: GC132_RS18225
• Protein ID: WP_003863437.1
• Coordinates: 3798118..3798384 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GC132_RS18200	3793725..3795458	-	1734	WP_038416675.1	single-stranded-DNA-specific exonuclease RecJ	-
GC132_RS18205	3795464..3796177	-	714	WP_022649304.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
GC132_RS18210	3796206..3797102	-	897	WP_003863442.1	site-specific tyrosine recombinase XerD	-
GC132_RS18215	3797204..3797725	+	522	WP_023306886.1	flavodoxin FldB	-
GC132_RS18220	3797727..3798137	-	411	WP_038416677.1	protein YgfX	Toxin
GC132_RS18225	3798118..3798384	-	267	WP_003863437.1	FAD assembly factor SdhE	Antitoxin
GC132_RS18230	3798679..3799659	+	981	WP_038416679.1	tRNA-modifying protein YgfZ	-
GC132_RS18235	3799745..3800404	-	660	WP_022649307.1	hemolysin III family protein	-
GC132_RS18240	3800671..3801402	+	732	WP_022649308.1	MurR/RpiR family transcriptional regulator	-
GC132_RS18245	3801519..3802952	+	1434	WP_038416681.1	6-phospho-beta-glucosidase BglA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16337.20 Da
• Isoelectric Point: 11.4775

>T141707 WP_038416677.1 NZ_CP045312:c3798137-3797727 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINSRQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Nucleotide

• Length: 411 bp

>T141707 NZ_CP060065:c4069773-4069486 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTGGTGTTTGATGATCCACAACATTTGTCACAGCAAGATCGCATAGAAAACGGTGAGTATCGCTGGCAGACTATCGGCG
TGGTTCACGGTATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAGTCGCTATGAGCATGGTTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10526.96 Da
• Isoelectric Point: 4.8310

>AT141707 WP_003863437.1 NZ_CP045312:c3798384-3798118 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Nucleotide

• Length: 267 bp

>AT141707 NZ_CP060065:c4069499-4069197 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAATTGAAGGCGCTGGCGAA
TAAATCCGACGAAGAGATTGATTACAGCGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACCCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGCTGAAGCGACCTGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Structures

Antitoxin

• AlphaFold DB: A0A837F8P5