Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1132339..1132960 Replicon chromosome
Accession NZ_CP045312
Organism Enterobacter hormaechei strain 14102KSN

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag GC132_RS05445 Protein ID WP_015571250.1
Coordinates 1132339..1132557 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag GC132_RS05450 Protein ID WP_006809850.1
Coordinates 1132586..1132960 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GC132_RS05415 1128351..1128611 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
GC132_RS05420 1128614..1128754 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
GC132_RS05425 1128751..1129461 - 711 WP_038415530.1 GNAT family N-acetyltransferase -
GC132_RS05430 1129564..1131024 + 1461 WP_038415532.1 PLP-dependent aminotransferase family protein -
GC132_RS05435 1130996..1131463 - 468 WP_022647269.1 hypothetical protein -
GC132_RS05440 1131580..1132131 - 552 WP_022647270.1 maltose O-acetyltransferase -
GC132_RS05445 1132339..1132557 - 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
GC132_RS05450 1132586..1132960 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
GC132_RS05455 1133470..1136616 - 3147 WP_023299464.1 multidrug efflux RND transporter permease subunit -
GC132_RS05460 1136639..1137832 - 1194 WP_022647272.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T141697 WP_015571250.1 NZ_CP045312:c1132557-1132339 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T141697 NZ_CP060065:2019078-2019181 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT141697 WP_006809850.1 NZ_CP045312:c1132960-1132586 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT141697 NZ_CP060065:c2019219-2018948 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References