Detailed information of TA system TA141695

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 3837838..3839411
• Replicon: chromosome
• Accession: NZ_CP045311
• Organism: Aeromonas dhakensis strain Aer_OnIF1

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: GB930_RS17435
• Protein ID: WP_242761662.1
• Coordinates: 3837838..3839157 (-)
• Length: 440 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A3Q8DTG9
• Locus tag: GB930_RS17440
• Protein ID: WP_042047685.1
• Coordinates: 3839157..3839411 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GB930_RS17420 (GB930_17445)	3833730..3834494	+	765	WP_242761656.1	ATP-binding cassette domain-containing protein	-
GB930_RS17425 (GB930_17450)	3834513..3835439	+	927	WP_242761658.1	ABC transporter substrate-binding protein	-
GB930_RS17430 (GB930_17455)	3835436..3837418	+	1983	WP_242761660.1	Fe(3+)-hydroxamate ABC transporter permease FhuB	-
GB930_RS17435 (GB930_17460)	3837838..3839157	-	1320	WP_242761662.1	type II toxin-antitoxin system HipA family toxin	Toxin
GB930_RS17440 (GB930_17465)	3839157..3839411	-	255	WP_042047685.1	helix-turn-helix domain-containing protein	Antitoxin
GB930_RS17445 (GB930_17470)	3839948..3840565	+	618	WP_242761664.1	recombinase family protein	-
GB930_RS17450 (GB930_17475)	3840562..3840885	-	324	WP_101778626.1	hypothetical protein	-
GB930_RS17455 (GB930_17480)	3841624..3844089	+	2466	WP_242761666.1	DEAD/DEAH box helicase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	ampH	-	3813363..3869395	56032

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 440 a.a.
• Molecular weight: 49545.47 Da
• Isoelectric Point: 6.6626

>T141695 WP_242761662.1 NZ_CP045311:c3839157-3837838 [Aeromonas dhakensis]
MANLAVYMNGYRVGTFTKTTSGAHQFQYHESWLAQSGSRPISLSMPLRHQAYRGDEAYNFFDNLLPDNTEVRNRVVARYQ
AASTQPFDLLSCIGQDSVGALQLVTEGHDVPDVRRIDYKALSDDELEQILTSYKSGIPLGMVREQEEFRISIAGAQEKTA
LLYLDDRWYLPLNATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKEFGLPVPHCFMMQVGQVKALAVERFDRR
YAADRSWIMRLPQEDFCQVLNVPSARKYENHGGPGITDIMKTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSVYPVFGGRGLNRRDAKLAMGLASSKGKKYAIEQIFPRHFFQTAKAVGFERSAMEEILTELANSV
DDVIERVTQQLPAGFPDTISSTILEGLKARSARLIKGWD

Nucleotide

• Length: 1320 bp

>T141695 NZ_CP060065:1007818-1008153 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9293.62 Da
• Isoelectric Point: 7.9834

>AT141695 WP_042047685.1 NZ_CP045311:c3839411-3839157 [Aeromonas dhakensis]
MKVTSAKQLSACIKDARLSQKLSQGKVAEKVGIRQDTVSSFELNPESTKLETLFKILAALELSLDIKPRNESSDSPASGW
KEEW

Nucleotide

• Length: 255 bp

>AT141695 NZ_CP060065:1007570-1007818 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A3Q8DTG9