Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 2430818..2432539 Replicon chromosome
Accession NZ_CP045306
Organism Legionella longbeachae strain B1445CHC

Toxin (Protein)


Gene name mosT Uniprot ID -
Locus tag GCB94_RS11800 Protein ID WP_165898406.1
Coordinates 2430818..2431750 (-) Length 311 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID -
Locus tag GCB94_RS11805 Protein ID WP_165898408.1
Coordinates 2431754..2432539 (-) Length 262 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GCB94_RS11785 2427772..2428437 - 666 WP_165898401.1 SOS response-associated peptidase -
GCB94_RS11790 2428514..2429767 - 1254 WP_165898402.1 Y-family DNA polymerase -
GCB94_RS11795 2429770..2430291 - 522 WP_165898404.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
GCB94_RS11800 2430818..2431750 - 933 WP_165898406.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
GCB94_RS11805 2431754..2432539 - 786 WP_165898408.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
GCB94_RS11810 2433081..2433188 - 108 WP_158304179.1 transposase -
GCB94_RS11815 2433245..2433481 + 237 WP_003636598.1 hypothetical protein -
GCB94_RS11820 2433948..2434394 - 447 WP_003636595.1 hypothetical protein -
GCB94_RS11825 2434562..2434864 - 303 WP_003636593.1 putative addiction module antidote protein -
GCB94_RS11830 2434861..2435199 - 339 WP_003636592.1 type II toxin-antitoxin system RelE/ParE family toxin -
GCB94_RS18570 2435907..2436023 - 117 WP_003636588.1 AAA family ATPase -
GCB94_RS11840 2436138..2436314 + 177 WP_003636586.1 DUF1016 family protein -
GCB94_RS11845 2436466..2437029 - 564 WP_080619678.1 ATP-binding cassette domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2379122..2435444 56322


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(13-264)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(96-254)


Sequences

Toxin        


Download         Length: 311 a.a.        Molecular weight: 35279.09 Da        Isoelectric Point: 6.7242

>T141692 WP_165898406.1 NZ_CP045306:c2431750-2430818 [Legionella longbeachae]
MNKQSPYYKQVLLLIRLIPLVEKETCFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPREIALANVRNALAGIAANINKI
PDLNAVLQDNKPDEMRIIVEDHSSLNRGTQIKIEVSPVARGTLLPPVELDVVASVENEFGFASMKVVSLPDLYGGKLCAA
LDRQHPRDLFDVKVLLENQKIDRELFNGFLTYLLSHKRPISEIMNPRWKDITQVFEREFKGMTAEPVTLEELTAIPEKMI
QGLKGNFTQQDYDFLVSFKKGDPEWSLACSDQIQNLPAVQWKLLNIRKMPKQKLMDSVSLLQRTMGYWLN

Download         Length: 933 bp

>T141692 NZ_CP060065:699296-699610 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 262 a.a.        Molecular weight: 29493.88 Da        Isoelectric Point: 9.6566

>AT141692 WP_165898408.1 NZ_CP045306:c2432539-2431754 [Legionella longbeachae]
MSSKINWLLNNIASGEILLQSWLSSHGITPQLARKYCQSQWLVKLGVGVYYRAGRKPEWQNAVYCLQNQSKSTIHLAGLT
SLTQQGKAHYLQLTTQSIWINIQAKSILPKWFKTFPELAISSNPAPEWEIIKTSKLNARDDNDLITIEVDGVKLKASNQE
LAAFEVLEAVPSIMSFEHAAELFQGLVNLSPKKVEDILKRSGSIQTNRLFLFFGHFYKHPWAGRVNESLINLGAGKRQIV
PDGRLEKQYQITVPEQFISSD

Download         Length: 786 bp

>AT141692 NZ_CP060065:699607-700023 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References