Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 48453..48987 Replicon plasmid pB1445CHC_150k
Accession NZ_CP045305
Organism Legionella longbeachae strain B1445CHC

Toxin (Protein)


Gene name relE Uniprot ID A0A7G4RL39
Locus tag GCB94_RS00565 Protein ID WP_014845122.1
Coordinates 48453..48734 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7G4RL40
Locus tag GCB94_RS00570 Protein ID WP_014845121.1
Coordinates 48727..48987 (-) Length 87 a.a.

Genomic Context

GCB94_RS00540GCB94_RS00545GCB94_RS00550GCB94_RS00555GCB94_RS00560GCB94_RS00575GCB94_RS00580GCB94_RS00585GCB94_RS00590GCB94_RS00610GCB94_RS00565GCB94_RS00570GCB94_RS00595GCB94_RS00600GCB94_RS00605
Location: 43872..44195 (324 bp)
Type: Others
Protein ID: WP_014845127.1
Location: 44248..45066 (819 bp)
Type: Others
Protein ID: WP_014845126.1
Location: 45105..45458 (354 bp)
Type: Others
Protein ID: WP_014845125.1
Location: 45436..45726 (291 bp)
Type: Others
Protein ID: WP_014845124.1
Location: 45775..48273 (2499 bp)
Type: Others
Protein ID: WP_014845123.1
Location: 49200..50084 (885 bp)
Type: Others
Protein ID: WP_014845120.1
Location: 50190..50537 (348 bp)
Type: Others
Protein ID: WP_080031944.1
Location: 50646..50879 (234 bp)
Type: Others
Protein ID: WP_014845118.1
Location: 50866..51186 (321 bp)
Type: Others
Protein ID: WP_014845117.1
Location: 53500..53655 (156 bp)
Type: Others
Protein ID: WP_154080667.1
Location: 48453..48734 (282 bp)
Type: Toxin
Protein ID: WP_014845122.1
Location: 48727..48987 (261 bp)
Type: Antitoxin
Protein ID: WP_014845121.1
Location: 51624..52016 (393 bp)
Type: Others
Protein ID: Protein_55
Location: 52382..52915 (534 bp)
Type: Others
Protein ID: WP_061637559.1
Location: 52937..53428 (492 bp)
Type: Others
Protein ID: WP_051009158.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GCB94_RS0054043872..44195+324WP_014845127.1hypothetical protein-
GCB94_RS0054544248..45066+819WP_014845126.1hypothetical protein-
GCB94_RS0055045105..45458+354WP_014845125.1type II toxin-antitoxin system RelE/ParE family toxin-
GCB94_RS0055545436..45726+291WP_014845124.1helix-turn-helix domain-containing protein-
GCB94_RS0056045775..48273+2499WP_014845123.1DEAD/DEAH box helicase family protein-
GCB94_RS0056548453..48734-282WP_014845122.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
GCB94_RS0057048727..48987-261WP_014845121.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
GCB94_RS0057549200..50084+885WP_014845120.1recombinase family protein-
GCB94_RS0058050190..50537+348WP_080031944.1WGR domain-containing protein-
GCB94_RS0058550646..50879+234WP_014845118.1hypothetical protein-
GCB94_RS0059050866..51186+321WP_014845117.1type II toxin-antitoxin system PemK/MazF family toxin-
GCB94_RS0059551624..52016-393Protein_55methyltransferase domain-containing protein-
GCB94_RS0060052382..52915-534WP_061637559.1IS91 family transposase-
GCB94_RS0060552937..53428-492WP_051009158.1IS91 family transposase-
GCB94_RS0061053500..53655+156WP_154080667.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmidblaOXA-29-1..150426150426


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-74)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11028.69 Da        Isoelectric Point: 8.9816

>T141690 WP_014845122.1 NZ_CP045305:c48734-48453 [Legionella longbeachae]
MLELELATQFKRDLKKITKQGKRRTLLDSIVEQLQKEEPLDPKHKDHSLSVNWDGYRECHITPDWLLIYKTIKDDRIQLL
RLSRTGSHSDLFG

Download         Length: 282 bp

>T141690 NZ_CP060065:196976-197083 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9594.08 Da        Isoelectric Point: 6.9803

>AT141690 WP_014845121.1 NZ_CP045305:c48987-48727 [Legionella longbeachae]
MNKAATINARIEPALKMQAEAILHKVGLSTAEAIRLFYSQVCLQNGLPFEVKIPNKETREAMAELESGKGERFKTMKDVW
DSVDNA

Download         Length: 261 bp

>AT141690 NZ_CP060065:c196928-196862 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A7G4RL39

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A7G4RL40

References