Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 48453..48987 Replicon plasmid pB1445CHC_150k
Accession NZ_CP045305
Organism Legionella longbeachae strain B1445CHC

Toxin (Protein)


Gene name relE Uniprot ID A0A7G4RL39
Locus tag GCB94_RS00565 Protein ID WP_014845122.1
Coordinates 48453..48734 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7G4RL40
Locus tag GCB94_RS00570 Protein ID WP_014845121.1
Coordinates 48727..48987 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GCB94_RS00540 43872..44195 + 324 WP_014845127.1 hypothetical protein -
GCB94_RS00545 44248..45066 + 819 WP_014845126.1 hypothetical protein -
GCB94_RS00550 45105..45458 + 354 WP_014845125.1 type II toxin-antitoxin system RelE/ParE family toxin -
GCB94_RS00555 45436..45726 + 291 WP_014845124.1 helix-turn-helix domain-containing protein -
GCB94_RS00560 45775..48273 + 2499 WP_014845123.1 DEAD/DEAH box helicase family protein -
GCB94_RS00565 48453..48734 - 282 WP_014845122.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
GCB94_RS00570 48727..48987 - 261 WP_014845121.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GCB94_RS00575 49200..50084 + 885 WP_014845120.1 recombinase family protein -
GCB94_RS00580 50190..50537 + 348 WP_080031944.1 WGR domain-containing protein -
GCB94_RS00585 50646..50879 + 234 WP_014845118.1 hypothetical protein -
GCB94_RS00590 50866..51186 + 321 WP_014845117.1 type II toxin-antitoxin system PemK/MazF family toxin -
GCB94_RS00595 51624..52016 - 393 Protein_55 methyltransferase domain-containing protein -
GCB94_RS00600 52382..52915 - 534 WP_061637559.1 IS91 family transposase -
GCB94_RS00605 52937..53428 - 492 WP_051009158.1 IS91 family transposase -
GCB94_RS00610 53500..53655 + 156 WP_154080667.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaOXA-29 - 1..150426 150426


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-74)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11028.69 Da        Isoelectric Point: 8.9816

>T141690 WP_014845122.1 NZ_CP045305:c48734-48453 [Legionella longbeachae]
MLELELATQFKRDLKKITKQGKRRTLLDSIVEQLQKEEPLDPKHKDHSLSVNWDGYRECHITPDWLLIYKTIKDDRIQLL
RLSRTGSHSDLFG

Download         Length: 282 bp

>T141690 NZ_CP060065:196976-197083 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9594.08 Da        Isoelectric Point: 6.9803

>AT141690 WP_014845121.1 NZ_CP045305:c48987-48727 [Legionella longbeachae]
MNKAATINARIEPALKMQAEAILHKVGLSTAEAIRLFYSQVCLQNGLPFEVKIPNKETREAMAELESGKGERFKTMKDVW
DSVDNA

Download         Length: 261 bp

>AT141690 NZ_CP060065:c196928-196862 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7G4RL39

Antitoxin

Source ID Structure
AlphaFold DB A0A7G4RL40

References