Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 274715..275379 Replicon plasmid unnamed1
Accession NZ_CP045303
Organism Azotobacter salinestris strain KACC 13899

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GCU53_RS25080 Protein ID WP_152390246.1
Coordinates 274945..275379 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GCU53_RS25075 Protein ID WP_152390245.1
Coordinates 274715..274945 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GCU53_RS25055 269722..270002 + 281 Protein_299 type II toxin-antitoxin system RelE/ParE family toxin -
GCU53_RS25060 270036..270335 + 300 WP_089169988.1 HigA family addiction module antidote protein -
GCU53_RS25065 270401..273097 - 2697 WP_152390243.1 M10 family metallopeptidase C-terminal domain-containing protein -
GCU53_RS25070 273341..274432 - 1092 WP_152390244.1 MBL fold metallo-hydrolase -
GCU53_RS25075 274715..274945 + 231 WP_152390245.1 antitoxin Antitoxin
GCU53_RS25080 274945..275379 + 435 WP_152390246.1 tRNA(fMet)-specific endonuclease VapC Toxin
GCU53_RS25630 276540..277228 - 689 Protein_306 hypothetical protein -
GCU53_RS25100 277476..277877 - 402 WP_152390249.1 biopolymer transporter ExbD -
GCU53_RS25105 277879..278589 - 711 WP_152390250.1 MotA/TolQ/ExbB proton channel family protein -
GCU53_RS25110 278640..279485 - 846 WP_152390251.1 energy transducer TonB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - adeG 1..321600 321600


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 16214.71 Da        Isoelectric Point: 6.8542

>T141687 WP_152390246.1 NZ_CP045303:274945-275379 [Azotobacter salinestris]
MLKFMLDTNICIFTIKNRPQLVREAFNRHHGQMCISTVTMMELIYGAEKSSNPERNLADVEGFAARLEVLKYDQDAAAHT
GQLRAELAKAGKQIGPYDQMIAGHARSQGLILVTNNLREFDRVPGLRVEDWVAPVLDRMDSPLC

Download         Length: 435 bp

>T141687 NZ_CP060061:c4821414-4821241 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8336.34 Da        Isoelectric Point: 4.5203

>AT141687 WP_152390245.1 NZ_CP045303:274715-274945 [Azotobacter salinestris]
MEQGSVFLSNRSQAVRLPKAAALPDGVKRVDVVAVGRARIITPAGECWDSWFDGEGVTADFMAEREQPANQEREAF

Download         Length: 231 bp

>AT141687 NZ_CP060061:c4821738-4821442 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References