Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-YefM
Location 210081..210754 Replicon plasmid unnamed1
Accession NZ_CP045303
Organism Azotobacter salinestris strain KACC 13899

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GCU53_RS24735 Protein ID WP_152390200.1
Coordinates 210332..210754 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GCU53_RS24730 Protein ID WP_152390199.1
Coordinates 210081..210332 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GCU53_RS24695 205339..205878 + 540 WP_152390196.1 flavin reductase family protein -
GCU53_RS24700 205995..206753 - 759 WP_152390056.1 IS5 family transposase -
GCU53_RS24710 206882..207124 - 243 WP_040107386.1 hypothetical protein -
GCU53_RS24720 208291..209286 - 996 Protein_235 IS4 family transposase -
GCU53_RS24725 209499..209939 + 441 WP_152390198.1 hypothetical protein -
GCU53_RS24730 210081..210332 + 252 WP_152390199.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GCU53_RS24735 210332..210754 + 423 WP_152390200.1 type II toxin-antitoxin system VapC family toxin Toxin
GCU53_RS25620 210837..211049 + 213 WP_167520119.1 hypothetical protein -
GCU53_RS24740 211030..211140 - 111 Protein_240 transposase -
GCU53_RS24745 211266..212276 - 1011 WP_152390201.1 helix-turn-helix domain-containing protein -
GCU53_RS24750 212557..213195 + 639 WP_152390202.1 IS6 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - adeG 1..321600 321600
- flank IS/Tn - - 207976..209286 1310


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-64)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15219.58 Da        Isoelectric Point: 6.7190

>T141685 WP_152390200.1 NZ_CP045303:210332-210754 [Azotobacter salinestris]
MFLLDTNVVSELRKAKQGKADTGVVAWAQSVQVGELYLSAISVMELETGVLLRERKDAAQGALLRAWLDQHVLPGFAGRI
LAVDTAVALRCARLHVPDQKSERDALIAATALVHSMTVVTRNVADFELTGVSILNPWSQQ

Download         Length: 423 bp

>T141685 NZ_CP060061:c4428308-4428021 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTGGTGTTTGATGATCCACAACATTTGTCACAGCAAGATCGCATAGAAAACGGTGAGTATCGCTGGCAGACTATCGGCG
TGGTTCACGGTATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAGTCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9128.45 Da        Isoelectric Point: 6.4559

>AT141685 WP_152390199.1 NZ_CP045303:210081-210332 [Azotobacter salinestris]
MPTTISSREFNHDTSRAKKAALTGPVFITDRGKPAHVLLCIEEYQRLTGSQPSIIDVLAMPVGEDVEFEAPRATIKTKPV
DFS

Download         Length: 252 bp

>AT141685 NZ_CP060061:c4428034-4427732 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAATTGAAGGCGCTGGCGAA
TAAATCCGACGAAGAGATTGATTACAGCGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACCCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGCTGAAGCGACCTGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References