Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 72355..73238 Replicon plasmid unnamed1
Accession NZ_CP045303
Organism Azotobacter salinestris strain KACC 13899

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag GCU53_RS23980 Protein ID WP_152390067.1
Coordinates 72801..73238 (+) Length 146 a.a.

Antitoxin (Protein)


Gene name PrcA Uniprot ID -
Locus tag GCU53_RS23975 Protein ID WP_152390068.1
Coordinates 72355..72804 (+) Length 150 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GCU53_RS23945 67653..68627 + 975 WP_152390086.1 helix-turn-helix domain-containing protein -
GCU53_RS23950 68617..68784 - 168 WP_167520123.1 hypothetical protein -
GCU53_RS23955 68885..69247 + 363 Protein_86 helix-turn-helix domain containing protein -
GCU53_RS23960 69253..69855 - 603 Protein_87 SDR family NAD(P)-dependent oxidoreductase -
GCU53_RS23965 69876..70880 - 1005 WP_152390279.1 zinc-binding dehydrogenase -
GCU53_RS23970 70900..71853 - 954 WP_152390088.1 cyclase family protein -
GCU53_RS23975 72355..72804 + 450 WP_152390068.1 DUF2384 domain-containing protein Antitoxin
GCU53_RS23980 72801..73238 + 438 WP_152390067.1 RES family NAD+ phosphorylase Toxin
GCU53_RS23985 73427..73657 + 231 WP_152390089.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
GCU53_RS23990 73654..74064 + 411 WP_152390090.1 type II toxin-antitoxin system VapC family toxin -
GCU53_RS23995 74095..74956 + 862 WP_152390091.1 IS5 family transposase -
GCU53_RS24000 74943..76199 - 1257 WP_152390092.1 IS701 family transposase -
GCU53_RS24005 76286..76717 - 432 WP_152390093.1 IS200/IS605 family transposase -
GCU53_RS24010 76824..77156 - 333 WP_152390094.1 DUF2790 domain-containing protein -
GCU53_RS25810 77655..77993 - 339 WP_208845542.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - adeG 1..321600 321600


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-140)

Antitoxin

Antitoxin Xre

(23-147)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15876.30 Da        Isoelectric Point: 5.5399

>T141681 WP_152390067.1 NZ_CP045303:72801-73238 [Azotobacter salinestris]
VILWRISAYADLSGVGGLRASGRWHHLGRPVVYAADSPAGAMLEVLVHLEIDPEDFPTTLQLIRIELPDPVSRAELPPLP
EHWKSAPEVTRAMGDRFLDGRSALLLPVPSAIIPCTTNYLFNPVHPEASGASIQVEKFPLDSRLI

Download         Length: 438 bp

>T141681 NZ_CP060061:3016822-3016929 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 16938.48 Da        Isoelectric Point: 6.7345

>AT141681 WP_152390068.1 NZ_CP045303:72355-72804 [Azotobacter salinestris]
MLAEVLRDHGYTAYRARLQSLLDIPESATDFEIHTRITKGFPATRLVQLTEAGVVTPLERDQIIPLRTLKSRIERDQPLT
VEESDRFFRAAHITAMAEAVFGDREKAKRWLSKPKERFSGLTPMQMLTTQQGTSQVEEMLLQIAEGLAL

Download         Length: 450 bp

>AT141681 NZ_CP060061:c3016775-3016709 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References