Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 4595943..4596608 Replicon chromosome
Accession NZ_CP045302
Organism Azotobacter salinestris strain KACC 13899

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag GCU53_RS21760 Protein ID WP_152389436.1
Coordinates 4596417..4596608 (-) Length 64 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag GCU53_RS21755 Protein ID WP_152389435.1
Coordinates 4595943..4596365 (-) Length 141 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GCU53_RS21700 4591160..4591822 + 663 WP_152389425.1 Replication protein P -
GCU53_RS25580 4591815..4591976 + 162 WP_167520096.1 hypothetical protein -
GCU53_RS21705 4591973..4592164 + 192 WP_152389426.1 hypothetical protein -
GCU53_RS25585 4592157..4592327 + 171 WP_167520097.1 hypothetical protein -
GCU53_RS21710 4592320..4593198 + 879 WP_167520098.1 ead/Ea22-like family protein -
GCU53_RS21715 4593191..4593373 + 183 WP_152389428.1 hypothetical protein -
GCU53_RS21720 4593366..4593788 + 423 WP_152389429.1 recombination protein NinB -
GCU53_RS21725 4593770..4594087 + 318 WP_208845376.1 DUF1364 family protein -
GCU53_RS21730 4594084..4594686 + 603 WP_152389431.1 KilA-N domain-containing protein -
GCU53_RS21735 4594783..4595019 + 237 WP_152389432.1 hypothetical protein -
GCU53_RS21740 4595006..4595371 + 366 WP_152389433.1 endodeoxyribonuclease RusA -
GCU53_RS21745 4595368..4595733 + 366 WP_152389434.1 hypothetical protein -
GCU53_RS21755 4595943..4596365 - 423 WP_152389435.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GCU53_RS21760 4596417..4596608 - 192 WP_152389436.1 type II toxin-antitoxin system HicA family toxin Toxin
GCU53_RS21765 4596754..4597074 + 321 WP_152389437.1 phage holin, lambda family -
GCU53_RS21770 4597079..4597705 + 627 WP_152389438.1 hypothetical protein -
GCU53_RS21775 4597695..4598888 + 1194 WP_152389439.1 PBSX family phage terminase large subunit -
GCU53_RS21780 4598897..4600306 + 1410 WP_152389440.1 DUF1073 domain-containing protein -
GCU53_RS21785 4600257..4601111 + 855 WP_167520099.1 phage head morphogenesis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4570841..4621343 50502


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-61)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-63)


Sequences

Toxin        


Download         Length: 64 a.a.        Molecular weight: 7173.19 Da        Isoelectric Point: 10.6196

>T141674 WP_152389436.1 NZ_CP045302:c4596608-4596417 [Azotobacter salinestris]
MKYNEFRRWLEAQGVEFTKSRGGSSHFKIKAPNGKQTIFPNHGAKEIGEGLRKDIIKQLGLND

Download         Length: 192 bp

>T141674 NZ_CP060061:c2066983-2065661 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 15116.17 Da        Isoelectric Point: 4.9121

>AT141674 WP_152389435.1 NZ_CP045302:c4596365-4595943 [Azotobacter salinestris]
MYDYPITAHDEAGHFWSSCPDIPEAHSAGDTIEELLANAVDGICLALTIYVDQVRSIPPASPAGEGQHVVHLPAQAVAKI
ALWNTMREQGLRVADLARLLEVSHPVASRLVDFDHTSKMEQIERALAALGKRLAVSVEAA

Download         Length: 423 bp

>AT141674 NZ_CP060061:c2067249-2066983 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAAATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References