Detailed information of TA system TA141668

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4316489..4317272
• Replicon: chromosome
• Accession: NZ_CP045300
• Organism: Kosakonia arachidis strain KACC 18508

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: GCU50_RS21380
• Protein ID: WP_090126338.1
• Coordinates: 4316489..4316863 (-)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: GCU50_RS21385
• Protein ID: WP_090126341.1
• Coordinates: 4316913..4317272 (-)
• Length: 120 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GCU50_RS21370	4314961..4315950	+	990	WP_090126335.1	glycosyltransferase	-
GCU50_RS21375	4316089..4316409	+	321	WP_090126525.1	hypothetical protein	-
GCU50_RS21380	4316489..4316863	-	375	WP_090126338.1	TA system toxin CbtA family protein	Toxin
GCU50_RS21385	4316913..4317272	-	360	WP_090126341.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
GCU50_RS21390	4317295..4317516	-	222	WP_004114632.1	DUF987 domain-containing protein	-
GCU50_RS21395	4317530..4318012	-	483	WP_090126344.1	DNA repair protein RadC	-
GCU50_RS21405	4318253..4318732	-	480	WP_090126350.1	antirestriction protein	-
GCU50_RS21410	4318811..4319632	-	822	WP_090126353.1	DUF945 domain-containing protein	-
GCU50_RS21415	4319743..4319955	-	213	WP_090126356.1	hypothetical protein	-
GCU50_RS21420	4320036..4320395	-	360	WP_090126359.1	hypothetical protein	-
GCU50_RS21425	4320450..4320860	-	411	WP_090126529.1	hypothetical protein	-
GCU50_RS21430	4320968..4321645	-	678	WP_038418587.1	WYL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4259428..4334150	74722

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (9-112)

Antitoxin

• Antitoxin CbeA (15-114)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 13791.67 Da
• Isoelectric Point: 7.2755

>T141668 WP_090126338.1 NZ_CP045300:c4316863-4316489 [Kosakonia arachidis]
MQIQSMPPQRAASSRLSSVEIWQKLLEYLLEQHYGLTLNDTPFGNDSVIQKHIDAGISLCDAVNFIVEKYDLVRTDRHGF
SVKEQSPFIGSIDMLRARKATGLMTLNGYQTVTDITSGRSSGGK

Nucleotide

• Length: 375 bp

>T141668 NZ_CP060061:646280-646594 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin

Protein

• Length: 120 a.a.
• Molecular weight: 13297.46 Da
• Isoelectric Point: 7.6932

>AT141668 WP_090126341.1 NZ_CP045300:c4317272-4316913 [Kosakonia arachidis]
MKKATRVINHNIAEPWWGLRRNITPCLGARLVQEGNCLHYLADRASIAGTFNDADLRHLDQAFPVLMKQMELMLTSNELT
PHIQRCITLHAKGLICEADTLGSCGYLYIVIYPTSATTA

Nucleotide

• Length: 360 bp

>AT141668 NZ_CP060061:646591-647007 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA