Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yeeU/CbtA-CbeA
Location 2546682..2547395 Replicon chromosome
Accession NZ_CP045300
Organism Kosakonia arachidis strain KACC 18508

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag GCU50_RS12645 Protein ID WP_090122177.1
Coordinates 2546682..2547020 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag GCU50_RS12650 Protein ID WP_090122175.1
Coordinates 2547045..2547395 (-) Length 117 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GCU50_RS12615 2543019..2543567 - 549 WP_090122181.1 hypothetical protein -
GCU50_RS12625 2544217..2545014 - 798 WP_090122180.1 helix-turn-helix domain-containing protein -
GCU50_RS12630 2545130..2545405 - 276 WP_086530362.1 type II toxin-antitoxin system RelE/ParE family toxin -
GCU50_RS12635 2545409..2545657 - 249 WP_090122178.1 ribbon-helix-helix domain-containing protein -
GCU50_RS12640 2545734..2546567 - 834 WP_090122755.1 DUF4942 domain-containing protein -
GCU50_RS12645 2546682..2547020 - 339 WP_090122177.1 TA system toxin CbtA family protein Toxin
GCU50_RS12650 2547045..2547395 - 351 WP_090122175.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
GCU50_RS12655 2547416..2547637 - 222 WP_090122174.1 DUF987 domain-containing protein -
GCU50_RS12660 2547651..2548133 - 483 WP_090122173.1 DNA repair protein RadC -
GCU50_RS12665 2548169..2548990 - 822 WP_090122171.1 DUF945 domain-containing protein -
GCU50_RS12670 2549101..2549313 - 213 WP_090122170.1 hypothetical protein -
GCU50_RS12675 2549394..2549753 - 360 WP_090122168.1 hypothetical protein -
GCU50_RS12680 2549807..2550271 - 465 WP_090122167.1 hypothetical protein -
GCU50_RS12685 2550325..2551002 - 678 WP_090122165.1 WYL domain-containing protein -
GCU50_RS12690 2551063..2551791 - 729 WP_090122164.1 DUF3944 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2528871..2564033 35162


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(3-108)

Antitoxin

Antitoxin CbeA

(15-115)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12847.79 Da        Isoelectric Point: 8.0567

>T141666 WP_090122177.1 NZ_CP045300:c2547020-2546682 [Kosakonia arachidis]
MKTPPVNQRVAKPCPPPVLVWQTLLTRLLEQHYGLTLNDTPFSDESVIQEHIDAGITLADAVNFLVEKYELVRIDRKGFS
WQEQSPYLRAVDILRARQATGLLRQSHNLLTR

Download         Length: 339 bp

>T141666 NZ_CP060061:181280-181387 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 117 a.a.        Molecular weight: 13370.09 Da        Isoelectric Point: 6.2053

>AT141666 WP_090122175.1 NZ_CP045300:c2547395-2547045 [Kosakonia arachidis]
MQNKRKIAVQDIAEPWWGLRSDFSPCFSARLAQEDNQLHYLADRASFNGQFSDADLRHLDLAFPVLMKQLELMLTSGELN
PRHQHCVTLYHNELTCEADTHGSCGYVYLAIYPTQR

Download         Length: 351 bp

>AT141666 NZ_CP060061:c181231-181168 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References