141652

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 3741365..3741973 Replicon chromosome
Accession NZ_CP045298
Organism Paenibacillus brasilensis strain KACC 13842

Toxin (Protein)


Gene name pemK Uniprot ID H6CFY1
Locus tag GCU48_RS17705 Protein ID WP_007429335.1
Coordinates 3741623..3741973 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag GCU48_RS17700 Protein ID WP_170970806.1
Coordinates 3741365..3741616 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GCU48_RS17680 3736938..3737267 - 330 WP_152380924.1 hypothetical protein -
GCU48_RS17685 3737746..3738113 + 368 Protein_3359 class II fructose-bisphosphate aldolase -
GCU48_RS17690 3738300..3739574 + 1275 WP_025718661.1 outer membrane lipoprotein carrier protein LolA -
GCU48_RS17695 3739845..3741041 + 1197 WP_025718663.1 alanine racemase -
GCU48_RS17700 3741365..3741616 + 252 WP_170970806.1 ribbon-helix-helix protein, CopG family Antitoxin
GCU48_RS17705 3741623..3741973 + 351 WP_007429335.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
GCU48_RS17710 3742153..3744357 + 2205 WP_208811859.1 helix-hairpin-helix domain-containing protein -
GCU48_RS17715 3744477..3744611 - 135 WP_007429337.1 cortex morphogenetic protein CmpA -
GCU48_RS17720 3744755..3745243 + 489 WP_025718666.1 SprT family protein -
GCU48_RS17735 3745554..3746429 - 876 WP_152380926.1 Cof-type HAD-IIB family hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-36)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12822.77 Da        Isoelectric Point: 5.6195

>T141652 WP_007429335.1 NZ_CP045298:3741623-3741973 [Paenibacillus brasilensis]
MIVKRGDVFFADLSPVVGSEQGGVRPVLIIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAATHGFDRDSVVLLEQI
RTIDKQRLTDKITHLDEETMRKVSDSLQISLGLIDF

Download         Length: 351 bp

>T141652 NZ_CP060057:2252854-2252957 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9465.86 Da        Isoelectric Point: 6.4671

>AT141652 WP_170970806.1 NZ_CP045298:3741365-3741616 [Paenibacillus brasilensis]
MISLPDHLLQEVDGIVAMENSNRSEFIRQAMKLYVGERKKRYIREAMQRGYMEMAKINLTMASEAFHAEEDANSTLGRTV
SGV

Download         Length: 252 bp

>AT141652 NZ_CP060057:c2252995-2252724 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H6CFY1

Antitoxin

Source ID Structure

References