Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 4359655..4360290 Replicon chromosome
Accession NZ_CP045293
Organism Paenibacillus guangzhouensis strain KCTC 33171

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag GCU39_RS19625 Protein ID WP_026263981.1
Coordinates 4359655..4360005 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag GCU39_RS19630 Protein ID WP_018757642.1
Coordinates 4360009..4360290 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GCU39_RS19590 4355468..4355677 + 210 WP_152395055.1 small acid-soluble spore protein Tlp -
GCU39_RS19605 4356031..4356507 - 477 WP_152395056.1 SprT family protein -
GCU39_RS19610 4356612..4356959 + 348 WP_152395057.1 hydrolase/acyltransferase -
GCU39_RS19615 4357138..4357275 + 138 WP_152395058.1 cortex morphogenetic protein CmpA -
GCU39_RS19620 4357356..4359518 - 2163 WP_193726994.1 RNA-binding transcriptional accessory protein -
GCU39_RS19625 4359655..4360005 - 351 WP_026263981.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
GCU39_RS19630 4360009..4360290 - 282 WP_018757642.1 ribbon-helix-helix protein, CopG family Antitoxin
GCU39_RS19635 4360530..4361711 - 1182 WP_152395060.1 alanine racemase -
GCU39_RS19640 4361915..4363018 - 1104 WP_152395061.1 outer membrane lipoprotein carrier protein LolA -
GCU39_RS19645 4363237..4363485 + 249 WP_152395062.1 hypothetical protein -
GCU39_RS19650 4363564..4364235 - 672 WP_152397338.1 DUF559 domain-containing protein -
GCU39_RS19655 4364642..4364995 - 354 WP_152395063.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-45)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12906.84 Da        Isoelectric Point: 4.8837

>T141650 WP_026263981.1 NZ_CP045293:c4360005-4359655 [Paenibacillus guangzhouensis]
MIVKRGDVFFADLSPVVGSEQGGVRPVLIIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAETHGFDRDSVILLEQI
RTIDKQRLTDKITHLDEETMRKVDDGLQISIGLIEF

Download         Length: 351 bp

>T141650 NZ_CP060057:1969015-1969269 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10693.32 Da        Isoelectric Point: 8.4209

>AT141650 WP_018757642.1 NZ_CP045293:c4360290-4360009 [Paenibacillus guangzhouensis]
VSNVQNTKRIMISLPDNLLQEVDGIVAKENSNRSEFIRQAMKLYLMDRKKRYIRESMQRGYMEMAKINLTMASEAFYAEE
DAEGTLGRLVSGV

Download         Length: 282 bp

>AT141650 NZ_CP060057:1968767-1969018 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References