Detailed information of TA system TA141649

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/HTH_IclR(antitoxin)
• Location: 6344265..6345948
• Replicon: chromosome
• Accession: NZ_CP045291
• Organism: Delftia tsuruhatensis strain TR1180

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: GCS91_RS29245
• Protein ID: WP_154836065.1
• Coordinates: 6345094..6345948 (-)
• Length: 285 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: GCS91_RS29240
• Protein ID: WP_154836063.1
• Coordinates: 6344265..6345071 (-)
• Length: 269 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GCS91_RS29210	6340019..6340789	-	771	WP_012202888.1	SDR family oxidoreductase	-
GCS91_RS29215	6341344..6341619	+	276	WP_074931722.1	hypothetical protein	-
GCS91_RS29220	6341883..6342230	+	348	WP_017406311.1	type II toxin-antitoxin system RelE/ParE family toxin	-
GCS91_RS29225	6342227..6342535	+	309	WP_016452050.1	XRE family transcriptional regulator	-
GCS91_RS29230	6342548..6343309	-	762	WP_154836059.1	5'-methylthioadenosine/adenosylhomocysteine nucleosidase	-
GCS91_RS29235	6343413..6344210	-	798	WP_154836061.1	aspartate dehydrogenase	-
GCS91_RS29240	6344265..6345071	-	807	WP_154836063.1	IclR family transcriptional regulator	Antitoxin
GCS91_RS29245	6345094..6345948	-	855	WP_154836065.1	alpha/beta fold hydrolase	Toxin
GCS91_RS29250	6346118..6346648	-	531	WP_016449821.1	cupin domain-containing protein	-
GCS91_RS29255	6346848..6348044	-	1197	WP_154836067.1	MFS transporter	-
GCS91_RS29260	6348067..6348951	-	885	WP_016449823.1	NAD(P)-dependent oxidoreductase	-
GCS91_RS29265	6349088..6349678	-	591	WP_013804518.1	TetR/AcrR family transcriptional regulator	-
GCS91_RS29270	6349760..6350251	-	492	WP_016449824.1	Lrp/AsnC family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Alpha/beta hydrolase fold-1 (43-270)

Antitoxin

• Transcription regulator IclR, C-terminal (137-255)

Sequences

Toxin

Protein

• Length: 285 a.a.
• Molecular weight: 29464.86 Da
• Isoelectric Point: 7.7722

>T141649 WP_154836065.1 NZ_CP045291:c6345948-6345094 [Delftia tsuruhatensis]
MTPSVTACMEQRLQAQFPEHLIALPGGAQVAWREAGDTASDFAVVMLHGISSGAASWMDVALALAPRTRVLAWGAPGYGR
STPLTPAAPTGADYARVLEQSLQALGVRRCLLVGHSLGALMGTPWAVQAGAGRVQQLVLISPAGGYGAPGMGEQQAKVRQ
GRLAALQEKGIEGLAAAIDQRLVSPAAPEPVRQWVRWNTARLHAAGYAQAVELLCGSDLGQAAGRLAMPVEVWVGEHDVV
TPPAACAAWAARLGARYVTLAAAGHASVVEQPADVAQRLATLLT

Nucleotide

• Length: 855 bp

>T141649 NZ_CP060057:1968767-1969018 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Protein

• Length: 269 a.a.
• Molecular weight: 29075.13 Da
• Isoelectric Point: 5.3408

>AT141649 WP_154836063.1 NZ_CP045291:c6345071-6344265 [Delftia tsuruhatensis]
MSDTSETLSNDNDRYTVPALERGLRLLACFTPSQPVWSAPDLARTLALPRSTVFRMLTTLEGMGYLQRSGTEYRLGLAVL
RLGYDYLSTQPLAQLAEPVLQSLCDRLGFTTNLALLDGTSVVYVARIAPAGAFQGAVRVGSRLPAHATVLGRALLQDMDV
DQLRALFGGSELPQFSESTPRSVEQLLQLLQQDHERGYAMGEGFYEPGVSSIAAPVRDAQGRIVAGLGMAVAFTEIAPGR
MADWVEQVRAAADELAGHLRTQHPGFLR

Nucleotide

• Length: 807 bp

>AT141649 NZ_CP060057:1969015-1969269 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA