Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 15115..15752 Replicon plasmid pLAU-OXA3
Accession NZ_CP045280
Organism Escherichia coli strain LAU-OXA

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag GBF15_RS24725 Protein ID WP_024250608.1
Coordinates 15342..15752 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag GBF15_RS24720 Protein ID WP_024250607.1
Coordinates 15115..15345 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GBF15_RS24690 10646..11512 - 867 WP_004118283.1 replication initiation protein -
GBF15_RS25620 12047..12151 + 105 WP_032409716.1 hypothetical protein -
GBF15_RS24695 12280..12537 + 258 WP_000764642.1 hypothetical protein -
GBF15_RS24700 12595..13371 - 777 WP_000015958.1 site-specific integrase -
GBF15_RS24705 13368..14111 - 744 WP_000129823.1 hypothetical protein -
GBF15_RS24710 14162..14512 - 351 WP_000493378.1 hypothetical protein -
GBF15_RS24720 15115..15345 + 231 WP_024250607.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
GBF15_RS24725 15342..15752 + 411 WP_024250608.1 PIN domain-containing protein Toxin
GBF15_RS24730 15970..16944 + 975 Protein_18 AAA family ATPase -
GBF15_RS24735 16977..17582 - 606 WP_000509966.1 recombinase family protein -
GBF15_RS24740 17813..18517 + 705 WP_001067855.1 IS6-like element IS26 family transposase -
GBF15_RS24750 18598..20175 + 1578 WP_001323889.1 PAS domain-containing methyl-accepting chemotaxis protein -
GBF15_RS24755 20516..20743 - 228 WP_131199869.1 transposase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - wbtL 1..37385 37385


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-127)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14473.53 Da        Isoelectric Point: 4.5141

>T141645 WP_024250608.1 NZ_CP045280:15342-15752 [Escherichia coli]
VNRTYMLDTRLCAYIMREQPEAVLTRLEQAVLRGDRIVISAVTWAELSQAARASGPATQALADAFCASLDAVLAWDRAAV
DATTVIKAALAADGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPDLVLEDWVK

Download         Length: 411 bp

>T141645 NZ_CP060057:709954-710250 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8682.92 Da        Isoelectric Point: 7.9973

>AT141645 WP_024250607.1 NZ_CP045280:15115-15345 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGNCIILRPVRPSWRSFALMGKAAPDFMAERETVFSDQGRGEQ

Download         Length: 231 bp

>AT141645 NZ_CP060057:710252-710647 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References