Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazF-pemI/MazF(toxin) |
| Location | 5072574..5073210 | Replicon | chromosome |
| Accession | NZ_CP045272 | ||
| Organism | Priestia megaterium strain FDU301 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | D5DWT4 |
| Locus tag | FDZ14_RS26760 | Protein ID | WP_013055004.1 |
| Coordinates | 5072574..5072924 (-) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | pemI | Uniprot ID | D5DWT3 |
| Locus tag | FDZ14_RS26765 | Protein ID | WP_013055003.1 |
| Coordinates | 5072929..5073210 (-) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FDZ14_RS26725 | 5068156..5068950 | - | 795 | WP_013055011.1 | RNA polymerase sigma factor SigB | - |
| FDZ14_RS26730 | 5068916..5069401 | - | 486 | WP_016762758.1 | anti-sigma B factor RsbW | - |
| FDZ14_RS26735 | 5069398..5069730 | - | 333 | WP_013055009.1 | anti-sigma factor antagonist | - |
| FDZ14_RS26740 | 5069790..5070800 | - | 1011 | WP_013055008.1 | PP2C family protein-serine/threonine phosphatase | - |
| FDZ14_RS26745 | 5070814..5071215 | - | 402 | WP_013055007.1 | anti-sigma regulatory factor | - |
| FDZ14_RS26750 | 5071219..5071575 | - | 357 | WP_013055006.1 | STAS domain-containing protein | - |
| FDZ14_RS26755 | 5071578..5072414 | - | 837 | WP_013055005.1 | STAS domain-containing protein | - |
| FDZ14_RS26760 | 5072574..5072924 | - | 351 | WP_013055004.1 | type II toxin-antitoxin system endoribonuclease NdoA | Toxin |
| FDZ14_RS26765 | 5072929..5073210 | - | 282 | WP_013055003.1 | hypothetical protein | Antitoxin |
| FDZ14_RS26770 | 5073411..5074601 | - | 1191 | WP_171777780.1 | alanine racemase | - |
| FDZ14_RS26775 | 5074715..5075773 | - | 1059 | WP_016762756.1 | outer membrane lipoprotein carrier protein LolA | - |
| FDZ14_RS26780 | 5075832..5076197 | - | 366 | WP_025753519.1 | holo-ACP synthase | - |
| FDZ14_RS26785 | 5076261..5076863 | + | 603 | WP_013081417.1 | rhomboid family intramembrane serine protease | - |
| FDZ14_RS26790 | 5076872..5077843 | - | 972 | WP_034654859.1 | UV DNA damage repair endonuclease UvsE | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12991.96 Da Isoelectric Point: 4.8781
>T141608 WP_013055004.1 NZ_CP045272:c5072924-5072574 [Priestia megaterium]
MVVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDRVDEALQISVGLIDF
MVVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDRVDEALQISVGLIDF
Download Length: 351 bp
>T141608 NZ_CP060040:1514973-1515554 [Burkholderia cenocepacia]
ATGAACCCCGATACGATCCACGCGCGGCTCGCGTTCCTGCGCGAAGCCGAACGCCTGAAGGACGTGCTGCGCAGCGGCCA
CACGTCGGCCGGCCGCCCGGAAAGCACGGCCGAGCACAGCTGGCGGCTATGCCTGATGGCGCTCGTGTTCGCCGACGCGC
TGCCCGGCGTCGATACGCTGAAGCTGCTGAAACTGTGCGTCGTCCACGACCTCGGCGAGGCGCTGCACGGCGACATCCCT
GCGATCGAGCAGGCCGCGCATCCCGACAAGAGCGCACATGAACGCGACGACCTGCTGACGCTGACCGCGTCGCTCGACCG
TGCGGTGCGCGACGAGATCGTCGCGCTGTGGGACGAATACGAGGCGGCCGCCTCACCCGAAGCCCGCGCGGCGAAAGCGC
TCGACAAGCTCGAAACGATCCTGCAGCACAACCAGGGCAGCAATCCGCCCGATTTCGACTATGCGTTCAATCTCGGCTAC
GGCCGCCGCTATACCGACGCCGCGCCGCTGTTCCGCGCGATCCGCGAAATCGTCGACGCCGATACGCAGCGCAAGATCGA
CACGGGTGGGTACCGCGCATAG
ATGAACCCCGATACGATCCACGCGCGGCTCGCGTTCCTGCGCGAAGCCGAACGCCTGAAGGACGTGCTGCGCAGCGGCCA
CACGTCGGCCGGCCGCCCGGAAAGCACGGCCGAGCACAGCTGGCGGCTATGCCTGATGGCGCTCGTGTTCGCCGACGCGC
TGCCCGGCGTCGATACGCTGAAGCTGCTGAAACTGTGCGTCGTCCACGACCTCGGCGAGGCGCTGCACGGCGACATCCCT
GCGATCGAGCAGGCCGCGCATCCCGACAAGAGCGCACATGAACGCGACGACCTGCTGACGCTGACCGCGTCGCTCGACCG
TGCGGTGCGCGACGAGATCGTCGCGCTGTGGGACGAATACGAGGCGGCCGCCTCACCCGAAGCCCGCGCGGCGAAAGCGC
TCGACAAGCTCGAAACGATCCTGCAGCACAACCAGGGCAGCAATCCGCCCGATTTCGACTATGCGTTCAATCTCGGCTAC
GGCCGCCGCTATACCGACGCCGCGCCGCTGTTCCGCGCGATCCGCGAAATCGTCGACGCCGATACGCAGCGCAAGATCGA
CACGGGTGGGTACCGCGCATAG
Antitoxin
Download Length: 94 a.a. Molecular weight: 10691.22 Da Isoelectric Point: 8.5339
>AT141608 WP_013055003.1 NZ_CP045272:c5073210-5072929 [Priestia megaterium]
VSEASATTEILVRLPKNLVSELDLMVKQENGNRSDFIHQATKLYLRERKKRHIRESMRRGYMEMAKINLNIASEAFLAEY
EADHTVDRLVSGG
VSEASATTEILVRLPKNLVSELDLMVKQENGNRSDFIHQATKLYLRERKKRHIRESMRRGYMEMAKINLNIASEAFLAEY
EADHTVDRLVSGG
Download Length: 282 bp
>AT141608 NZ_CP060040:1514328-1514894 [Burkholderia cenocepacia]
ATGCCCCACCCGCCGCTTCATCCATCCTCGCTCGGCCCGCAACTCAAGCGCTGGCGCACGCTGCACCGCGTGAAGCAAAG
CCATGCAGCCGAGCTGTTCGGCGTCGCGCAATCGACGATCTCGCGCTGGGAAGCCGGCCTTCAGCAGATGTCGCCCGCCG
AGCGCGCGACGGCCGAACGGCTGCTCGCCGCGCGCCTCGATTCCGCGGGCGACCACGCACTCGCGCGGCTGATCGCCGGC
AGCGCGGGCCGCATGCATCTCGTGTGCGACCTCACGCACCGCCTGCTGGCCAGTTCCCCGGCGCGCGCGGCCGAGTTCTC
GCAACCGCTTTCGACGTTGCTCGGCACGTCGCTGTGGCGCTACGCGACACCGGAAATCGCCCGCATGGAAGCCGCGCTCG
ACCCGCTCGGCTGGCACGACCGCGCGGGGCCGCCGAGCGTCGAGTTCGACACCGGCGCGAATGCGTCGCGCGTCGTGCCG
ATTCGCGGCAGCCGATGCCGGTGGACACGGCTGACGCTGTCGGACGGCTCGGCCGTGCGGCTCGTGGAGACGCTCGACGC
ACACTGA
ATGCCCCACCCGCCGCTTCATCCATCCTCGCTCGGCCCGCAACTCAAGCGCTGGCGCACGCTGCACCGCGTGAAGCAAAG
CCATGCAGCCGAGCTGTTCGGCGTCGCGCAATCGACGATCTCGCGCTGGGAAGCCGGCCTTCAGCAGATGTCGCCCGCCG
AGCGCGCGACGGCCGAACGGCTGCTCGCCGCGCGCCTCGATTCCGCGGGCGACCACGCACTCGCGCGGCTGATCGCCGGC
AGCGCGGGCCGCATGCATCTCGTGTGCGACCTCACGCACCGCCTGCTGGCCAGTTCCCCGGCGCGCGCGGCCGAGTTCTC
GCAACCGCTTTCGACGTTGCTCGGCACGTCGCTGTGGCGCTACGCGACACCGGAAATCGCCCGCATGGAAGCCGCGCTCG
ACCCGCTCGGCTGGCACGACCGCGCGGGGCCGCCGAGCGTCGAGTTCGACACCGGCGCGAATGCGTCGCGCGTCGTGCCG
ATTCGCGGCAGCCGATGCCGGTGGACACGGCTGACGCTGTCGGACGGCTCGGCCGTGCGGCTCGTGGAGACGCTCGACGC
ACACTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|