Detailed information of TA system TA141607

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 1738..2318
• Replicon: plasmid p16HN-263_2
• Accession: NZ_CP045265
• Organism: Klebsiella pneumoniae strain 16HN-263

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A8J3DTL7
• Locus tag: ELO34_RS29260
• Protein ID: WP_071177730.1
• Coordinates: 2004..2318 (+)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A2X1PRM1
• Locus tag: ELO34_RS29255
• Protein ID: WP_000093040.1
• Coordinates: 1738..2016 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ELO34_RS29240	311..556	+	246	WP_032440458.1	hypothetical protein	-
ELO34_RS29245	830..1201	+	372	WP_001237044.1	cell envelope integrity protein TolA	-
ELO34_RS29250	1198..1404	+	207	Protein_2	TonB family protein	-
ELO34_RS29255	1738..2016	+	279	WP_000093040.1	CopG family ribbon-helix-helix protein	Antitoxin
ELO34_RS29260	2004..2318	+	315	WP_071177730.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ELO34_RS29265	2482..2910	+	429	WP_001140599.1	hypothetical protein	-
ELO34_RS29270	2936..3115	+	180	WP_000165970.1	Rop family plasmid primer RNA-binding protein	-
ELO34_RS29275	3142..3672	-	531	WP_071177729.1	hypothetical protein	-
ELO34_RS29280	3679..4410	-	732	WP_071177728.1	replication-relaxation family protein	-
ELO34_RS29285	4410..6374	-	1965	WP_071177727.1	TraM recognition domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..10060	10060

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-96)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 11805.73 Da
• Isoelectric Point: 9.8324

>T141607 WP_071177730.1 NZ_CP045265:2004-2318 [Klebsiella pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKTLPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDR
EMDQIVIVTVRHQKESGYPGADSL

Nucleotide

• Length: 315 bp

>T141607 NZ_CP060040:1441482-1441748 [Burkholderia cenocepacia]
ATGAGCGTACGTCGCGTGCTCTTTACTTCCGACGCATGGGATGACTATGTCTACTGGCAAGGACAGGATCGCAAGACGCT
CAAGCGCATCAACCAGCTCATTCGCGAAACCCAGCGCACGCCGTTCGAAGGCATCGGCAAGCCGGAGCCGTTGAAAGCCA
ATCTCTCCGGCTTCTGGTCGCGCCGTATCGACGATACGAACCGCCTGGTCTACGAGGCTGACGACCTTCAACTCAGCATC
GTGTCCTGCCGCTACCATTACGAGTAG

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10709.73 Da
• Isoelectric Point: 4.7561

>AT141607 WP_000093040.1 NZ_CP045265:1738-2016 [Klebsiella pneumoniae]
MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWG
TENEQDAPPCHR

Nucleotide

• Length: 279 bp

>AT141607 NZ_CP060040:1441225-1441485 [Burkholderia cenocepacia]
ATGCGCACGATTCATTTTTCGGATGCCCGCGGCAATCTGAAGACCGTCATCGACCAGGTCGTCGACGATGCGGACGTGAC
GCTCATTACGCGCCGCGATGCACCGAACGCCGTCATCATGTCGCAGGACTATTACGACAGCCTGATGGAGACGGTTCACC
TGCTGCGCTCGCCAGCCAACGTCGCTCACCTCGAACGTTCGATCGCGCAACTGCGCAAGGGCAAGGCGAAAGAACACAAG
CTCGCCGAGGATGATGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A2X1PRM1