Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 5068989..5069515 Replicon chromosome
Accession NZ_CP045263
Organism Klebsiella pneumoniae strain 16HN-263

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag ELO34_RS25675 Protein ID WP_000323025.1
Coordinates 5069228..5069515 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag ELO34_RS25670 Protein ID WP_000534858.1
Coordinates 5068989..5069228 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELO34_RS25645 5064051..5064755 + 705 WP_001067855.1 IS6-like element IS26 family transposase -
ELO34_RS25650 5064987..5066327 + 1341 WP_000589001.1 ISNCY family transposase -
ELO34_RS25655 5066748..5067059 + 312 Protein_4919 transposase -
ELO34_RS25665 5068310..5068726 + 417 Protein_4921 cation-efflux pump -
ELO34_RS25670 5068989..5069228 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
ELO34_RS25675 5069228..5069515 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
ELO34_RS25680 5069587..5069745 + 159 WP_004181898.1 type I toxin-antitoxin system Hok family toxin -
ELO34_RS29530 5070348..5071322 + 975 WP_004181899.1 hypothetical protein -
ELO34_RS25690 5071520..5071897 - 378 WP_004181901.1 hypothetical protein -
ELO34_RS25695 5072587..5073654 + 1068 WP_004181903.1 hypothetical protein -
ELO34_RS25700 5073810..5074157 + 348 WP_004181904.1 hypothetical protein -
ELO34_RS25705 5074236..5074469 + 234 WP_004181905.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element mph(E) iucA / iucB / iucC / iucD / iutA / rmpA 5051895..5201973 150078


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T141596 WP_000323025.1 NZ_CP045263:5069228-5069515 [Klebsiella pneumoniae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T141596 NZ_CP060037:266616-266897 [Sphingobium barthaii]
ATGCGGACGATTGAACGCTTCGGGCGGTTCAAGCGCGACTACAAGCGGGAGAAGAAGGGGCAGCACGCCAAGACGCTGGA
CGCTGACCTGATCCCGATCATCGAGGCGCTGGCATCCGACGAGCCGCTTGAACCGCGCCACCGCGACCATGCGCTGACCG
GCGACTGGCGCGACCATCGCGATTGCCACATAAAGCCCGACCTCGTGCTGATTTACCGCAAGCCCGATGACGACACCTTG
CAGCTTGTGCGCTTGGGATCGCACGCGGAATTGGGTTGGTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT141596 WP_000534858.1 NZ_CP045263:5068989-5069228 [Klebsiella pneumoniae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT141596 NZ_CP060037:266366-266629 [Sphingobium barthaii]
ATGGCCGCAAACGCTCTTGTGCAGACCCGGATCGACGGAGCGGTGAAGGAGGAAGCCGCGACCGTGCTGGCTGCTATGGG
GCTGACCGTCTCCGATGCCGTGCGCCTGATGCTGACCCGCGTTGCCCGCGACAAGGCCTTGCCGTTTGAACCGCTGGTGC
CCAATGCCGAGACGATCGAGGCCATGAAGGAAGCGCGCGAGGGAAAGGGCAAGCGGTTCGCCACGGTGGTCGACCTGATG
GCCGACCTCAATGCGGACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References