141596

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 5068989..5069515 Replicon chromosome
Accession NZ_CP045263
Organism Klebsiella pneumoniae strain 16HN-263

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag ELO34_RS25675 Protein ID WP_000323025.1
Coordinates 5069228..5069515 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag ELO34_RS25670 Protein ID WP_000534858.1
Coordinates 5068989..5069228 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELO34_RS25645 5064051..5064755 + 705 WP_001067855.1 IS6-like element IS26 family transposase -
ELO34_RS25650 5064987..5066327 + 1341 WP_000589001.1 ISNCY family transposase -
ELO34_RS25655 5066748..5067059 + 312 Protein_4919 transposase -
ELO34_RS25665 5068310..5068726 + 417 Protein_4921 cation-efflux pump -
ELO34_RS25670 5068989..5069228 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
ELO34_RS25675 5069228..5069515 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
ELO34_RS25680 5069587..5069745 + 159 WP_004181898.1 type I toxin-antitoxin system Hok family toxin -
ELO34_RS29530 5070348..5071322 + 975 WP_004181899.1 hypothetical protein -
ELO34_RS25690 5071520..5071897 - 378 WP_004181901.1 hypothetical protein -
ELO34_RS25695 5072587..5073654 + 1068 WP_004181903.1 hypothetical protein -
ELO34_RS25700 5073810..5074157 + 348 WP_004181904.1 hypothetical protein -
ELO34_RS25705 5074236..5074469 + 234 WP_004181905.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element mph(E) iucA / iucB / iucC / iucD / iutA / rmpA 5051895..5201973 150078


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T141596 WP_000323025.1 NZ_CP045263:5069228-5069515 [Klebsiella pneumoniae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T141596 NZ_CP060037:266616-266897 [Sphingobium barthaii]
ATGCGGACGATTGAACGCTTCGGGCGGTTCAAGCGCGACTACAAGCGGGAGAAGAAGGGGCAGCACGCCAAGACGCTGGA
CGCTGACCTGATCCCGATCATCGAGGCGCTGGCATCCGACGAGCCGCTTGAACCGCGCCACCGCGACCATGCGCTGACCG
GCGACTGGCGCGACCATCGCGATTGCCACATAAAGCCCGACCTCGTGCTGATTTACCGCAAGCCCGATGACGACACCTTG
CAGCTTGTGCGCTTGGGATCGCACGCGGAATTGGGTTGGTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT141596 WP_000534858.1 NZ_CP045263:5068989-5069228 [Klebsiella pneumoniae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT141596 NZ_CP060037:266366-266629 [Sphingobium barthaii]
ATGGCCGCAAACGCTCTTGTGCAGACCCGGATCGACGGAGCGGTGAAGGAGGAAGCCGCGACCGTGCTGGCTGCTATGGG
GCTGACCGTCTCCGATGCCGTGCGCCTGATGCTGACCCGCGTTGCCCGCGACAAGGCCTTGCCGTTTGAACCGCTGGTGC
CCAATGCCGAGACGATCGAGGCCATGAAGGAAGCGCGCGAGGGAAAGGGCAAGCGGTTCGCCACGGTGGTCGACCTGATG
GCCGACCTCAATGCGGACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References