Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4933092..4933608 Replicon chromosome
Accession NZ_CP045263
Organism Klebsiella pneumoniae strain 16HN-263

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag ELO34_RS24955 Protein ID WP_002886902.1
Coordinates 4933092..4933376 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag ELO34_RS24960 Protein ID WP_002886901.1
Coordinates 4933366..4933608 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELO34_RS24930 4928576..4928884 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
ELO34_RS24935 4928969..4929142 + 174 WP_002886906.1 hypothetical protein -
ELO34_RS24940 4929145..4929888 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
ELO34_RS24945 4930245..4932383 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
ELO34_RS24950 4932624..4933088 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
ELO34_RS24955 4933092..4933376 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ELO34_RS24960 4933366..4933608 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
ELO34_RS24965 4933686..4935596 - 1911 WP_004152270.1 BglG family transcription antiterminator -
ELO34_RS24970 4935619..4936773 - 1155 WP_002886900.1 lactonase family protein -
ELO34_RS24975 4936839..4937579 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T141595 WP_002886902.1 NZ_CP045263:c4933376-4933092 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T141595 NZ_CP060037:c110656-110234 [Sphingobium barthaii]
ATGATCGTTGTAGATACCAATGTCATTTCCGAAATGGCAAAACCGCAACCTTCGATTTCCGTCCGGCGCTGGCTTGATGC
CCAACCCTTTGATGCCCTTTATCTGACGACTATCACGATGGCGGAGATGCGTTTCGGCATCATGGTTCTACCTGCAAGCA
AGCGGCGGAGTTTTCTCGAAGCAGCGTTGGAGCGCACGGAACAGCTGTACGCAGGTCGAATCCTGTCGTTCGATCAGGAT
GCAGCGCGGCACTACGCGGACCTTGCCACTCTTGCCCGCGCGAAAGGCAAGGGGTTCCCCGCACCGGACGCCTATATTGC
GGCGATCGCGGCAGCTAACGGATTTATCGTCTCAACACGTGATACGGCACCATTCGAGGCCGCAGGCCTTGGCGTCATCA
ATCCCTGGCTCAGCACCAACTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT141595 WP_002886901.1 NZ_CP045263:c4933608-4933366 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT141595 NZ_CP060037:c110910-110656 [Sphingobium barthaii]
ATGGCATCCGTCACCGTTCGCAACATCCCGGATGAAGTTCATCGGGCTTTGCGCGTGCGCGCAGCCCAGCATGGCCGCAG
CACCGAAGCCGAAATTCGCATCATCCTGGAGCAGGCCGCGATGCCGGAGGGAAGAAGGCTCATGGGTTCGGCACTTTCCG
AAATCTGGGGCACCGCTGGGTTGACCGAGGAAGAGGCGGCGGCAATCGAAGGCGCGAGGGATCGCCGCCCCGCGACGCCA
ATGAGCTTCGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References