Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4214610..4215229 Replicon chromosome
Accession NZ_CP045263
Organism Klebsiella pneumoniae strain 16HN-263

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag ELO34_RS21415 Protein ID WP_002892050.1
Coordinates 4215011..4215229 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag ELO34_RS21410 Protein ID WP_002892066.1
Coordinates 4214610..4214984 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELO34_RS21400 4209762..4210955 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
ELO34_RS21405 4210978..4214124 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit -
ELO34_RS21410 4214610..4214984 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
ELO34_RS21415 4215011..4215229 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
ELO34_RS21420 4215388..4215954 + 567 WP_002892030.1 maltose O-acetyltransferase -
ELO34_RS21425 4215926..4216066 - 141 WP_004147370.1 hypothetical protein -
ELO34_RS21430 4216087..4216557 + 471 WP_002892026.1 YlaC family protein -
ELO34_RS21435 4216532..4217257 - 726 Protein_4119 PLP-dependent aminotransferase family protein -
ELO34_RS21440 4217325..4218517 + 1193 WP_085955245.1 IS3-like element ISKpn18 family transposase -
ELO34_RS21445 4218558..4219289 - 732 Protein_4121 PLP-dependent aminotransferase family protein -
ELO34_RS21450 4219390..4220088 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
ELO34_RS21455 4220085..4220225 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T141593 WP_002892050.1 NZ_CP045263:4215011-4215229 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T141593 NZ_CP060035:c148365-148183 [Sphingobium barthaii]
ATGGAACGGGACAGCAAAAAGATCGTCAGGCGGCTTCTGGAAGAGGGCTATGAACAGGTTTCGGTGAAGGGCTCTCACCA
CAAGTTCAGAAAGGGCGACCGGACGATCATCGTGCCCCACCCGAAGAAAGACCTGCCGCTGGGAACGGCACGAAGTATAG
CAAAGATGGCGGGGTGGCTGTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT141593 WP_002892066.1 NZ_CP045263:4214610-4214984 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT141593 NZ_CP060035:c148160-147768 [Sphingobium barthaii]
ATGAAATATTTTTACGCCATCGTTCACAAGGATGCGGACAGCGCCTTTGGTGTCAGCTTTCCCGATCTGCCGGGTTGCTT
CTCGGCGGCCGACCGTCAGGAAGACGTACTCCCCAATGCGGTGGAGGCGCTGGAACTGTGGTTTGAGGATGCGGAGGAAG
TCGATCCGCGCCCGGTCGATCAGGTGCGCGAAGCGGTGAAAGAGGATCTGGCGCAGGGCGCCTTCCTTCTTGCCGTTCCG
CGCATCACATCGGCCAACAAGCTCGCCCGCGTCAATCTGTCGTTGGATCGGGGCATGCTCGACGCCATCGATCAGGCGGC
AGCGCTTCGGAAGCTGACCCGCAGTGCGTTCATGGCGGAGGCGGCCAGGAACGAAATCGAAGGCCGCCATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References