Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2796299..2797887 Replicon chromosome
Accession NZ_CP045263
Organism Klebsiella pneumoniae strain 16HN-263

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag ELO34_RS14175 Protein ID WP_004199851.1
Coordinates 2796299..2797621 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag ELO34_RS14180 Protein ID WP_002904790.1
Coordinates 2797621..2797887 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELO34_RS14160 2791364..2793865 + 2502 WP_004199853.1 fimbrial biogenesis outer membrane usher protein -
ELO34_RS14165 2793853..2794857 + 1005 WP_004199852.1 type 1 fimbrial protein -
ELO34_RS14170 2794990..2796282 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
ELO34_RS14175 2796299..2797621 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
ELO34_RS14180 2797621..2797887 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
ELO34_RS14185 2798153..2798479 - 327 WP_002904788.1 hydroxyisourate hydrolase -
ELO34_RS14190 2798476..2798976 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
ELO34_RS14195 2798954..2800333 - 1380 WP_004199850.1 purine permease -
ELO34_RS14200 2800679..2801833 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
ELO34_RS14205 2801814..2802737 - 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T141592 WP_004199851.1 NZ_CP045263:c2797621-2796299 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T141592 NZ_CP060035:141026-141541 [Sphingobium barthaii]
ATGACGACACGCGCCGTTGCCGCGCCGACGCCGCTTCGTGCGGAGCATGATGCCGCCGCTTTTGCGTCCGGCCAACATGA
CACGCTCGATAGCTGGCTGAGGCAGCGCGCACTGACCAGCGAGGGCTTGTCGGCGCGCACCTATGTCATCTGCGATGCGG
CCGCGCCGCAGCGGATTGTCGGCTATTACACGATCACCACCGCGATGGAGCAGCGCGCGGCGTTGCCGAGCGCAAAGCTC
CGGCGAGCGATGCCCGAGCAGGTGCCGCTGCTGCTGGTCGCGCGGCTCGCGGTCGACCGCGAATGGCAAGGCCTGGGGCT
GGGCGGGGATCTTCTGGGCGACGCCCTCCGGCGGTGCTTTGCGGCATCGGTGATCGCCGGCGCCCGCGGCATAGCGGTCC
ATGCGATCGATGAGGCCGCCGCCCGCTTCTATGAGCATCATGGTTTCCTGCGATCGCCGTTGGGGGAGCTGACCCTGATC
CTCCCGATCGAGGCGCTGCGCGGGATTATTGACTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT141592 WP_002904790.1 NZ_CP045263:c2797887-2797621 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT141592 NZ_CP060035:140697-141005 [Sphingobium barthaii]
ATGGCGCGGGCGGAGAGCCACGGACGGGAACGGCGTGCGACGGCGCGCAAGGATGATGTCATCCAGGTGCGTGCGATGGC
GGGCACCAAGGCGCTGCTCAACCGCGCGGCGGCGATGCGCGGCCAGAAGCTGTCCGAGTTCATGCTGGAGAGCGCGCGGC
GCGAAGCGGAGAATGCTCTCCTCGACCAGCGCACCTTCTTCCTTGACGACGAACGCCATGCCGCGTTCGTGGTGATGCTC
GATGCACCCCACACGCCGTCCGAAAAGCTCAAGGAGCTGATGCATCGCAAGCCCGCCTGGGACCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References