Detailed information of TA system TA141583

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 875168..875822
• Replicon: chromosome
• Accession: NZ_CP045263
• Organism: Klebsiella pneumoniae strain 16HN-263

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: R4YHX2
• Locus tag: ELO34_RS04490
• Protein ID: WP_004144731.1
• Coordinates: 875415..875822 (+)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: W8UQ37
• Locus tag: ELO34_RS04485
• Protein ID: WP_002916312.1
• Coordinates: 875168..875434 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ELO34_RS04460	870324..871757	-	1434	WP_002916322.1	6-phospho-beta-glucosidase BglA	-
ELO34_RS04465	871876..872604	-	729	WP_002916321.1	MurR/RpiR family transcriptional regulator	-
ELO34_RS04470	872654..872965	+	312	WP_002916319.1	N(4)-acetylcytidine aminohydrolase	-
ELO34_RS04475	873129..873788	+	660	WP_002916317.1	hemolysin III family protein	-
ELO34_RS04480	873939..874922	-	984	WP_002916313.1	tRNA-modifying protein YgfZ	-
ELO34_RS04485	875168..875434	+	267	WP_002916312.1	FAD assembly factor SdhE	Antitoxin
ELO34_RS04490	875415..875822	+	408	WP_004144731.1	protein YgfX	Toxin
ELO34_RS04495	875829..876350	-	522	WP_002916308.1	flavodoxin FldB	-
ELO34_RS04500	876451..877347	+	897	WP_004144729.1	site-specific tyrosine recombinase XerD	-
ELO34_RS04505	877370..878083	+	714	WP_002916301.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
ELO34_RS04510	878089..879822	+	1734	WP_004151783.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 15936.69 Da
• Isoelectric Point: 11.4778

>T141583 WP_004144731.1 NZ_CP045263:875415-875822 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Nucleotide

• Length: 408 bp

>T141583 NZ_CP060018:3151209-3151802 [Mycolicibacterium holsaticum DSM 44478 = JCM 12374]
GTGAAGCGGCTCGACCTCGTCGTCGGCCCCAACGGTGCCGGCAAGTCCACCTTCATCGAGCTGACCTTGGCGCCCCTGCT
GCCTGGCAGCGTGGTGGTCAACGCCGACGAGATCGCCAAGCAGCGCTGGCCAGATGACCCCGCCTCACACGCCTATGAAG
CCGCACGGATCGCAGCCGCCACCAGAGAACGCCTGATCGAACTCGGCGAATCCTTCATCGCCGAGACCGTGTTCTCCCAC
CCTTCCAAGCTCGAGCTCCTCTACAGCGCACACCTGCGGGGGTACTCGGTGGTTGTGCACGCGGTTCTCATCCCCGAGCA
GCTCGCCGTGGCCAGGGTGCAACACCGAGTCGCCGCGGGCGGACATTCCGTGCCGGAAGCCAAGATTCGGGAACGCTACC
AACGGCTGTGGGCACTGGTCGCCCTCGCGGCTGCTCGGGCGGACTCAGCGACCTTTTACGACAACAGCGGCATCCGGGGA
CCCCGTATCGTTGCGCAGATGGCCGGCGGCTTCGTCGTGGGCTCCCTCCGCTGGCCGCAGTGGACCCCGGCGGCGCTCAC
CACGTGCTGGCCCAACCCGCCGGATCGCCGCTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10480.98 Da
• Isoelectric Point: 5.1116

>AT141583 WP_002916312.1 NZ_CP045263:875168-875434 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT141583 NZ_CP060018:3150788-3151177 [Mycolicibacterium holsaticum DSM 44478 = JCM 12374]
ATGACTGAGACGGCAGATCGGGTCACGCGGTTTGCCGCGGATCTGCTCGATAGCGCCGCGGCCGAGGGCGCGCGGCAGAG
TCGCTCAGCCAAACAGCAGCTCGATCATTGGGCACGAGTGGGTCGCGCGGTATCAGGACAGCACAGTGCGGCCCGACGCA
AGGTGGAGGCCGCGCTGAGCGGCGCAACTCCGCTGAGCGAGCTGAGCGCCGAGGAAGGTGTGGTGTTCAACGCTGAGATC
TCCGCCGCGATCCAAGAGAGACTGGCCGACACCGACTACGGCGCGACGTTGGCCGGCCGCGGTATCACCACCGTCGCACT
CAACGACGACGGCGAGCTGGTCCAGTACCGCCCCGATGGGACCTCGTCGACGCTGTCAGACCAGCGGTGA

Structures

Toxin

• AlphaFold DB: A0A378E4P6

Antitoxin

• AlphaFold DB: A0A0H3GY41