Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3506328..3506948 Replicon chromosome
Accession NZ_CP045258
Organism Yersinia pestis strain SCPM-O-B-5942 (I-2638)

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag GD372_RS16355 Protein ID WP_002208622.1
Coordinates 3506745..3506948 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q66DR4
Locus tag GD372_RS16350 Protein ID WP_002218472.1
Coordinates 3506328..3506696 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GD372_RS16335 3504523..3504783 + 261 WP_002208617.1 type B 50S ribosomal protein L31 -
GD372_RS16340 3504799..3504942 + 144 WP_002208618.1 type B 50S ribosomal protein L36 -
GD372_RS16345 3505816..3506169 + 354 WP_002208619.1 hypothetical protein -
GD372_RS16350 3506328..3506696 + 369 WP_002218472.1 Hha toxicity modulator TomB Antitoxin
GD372_RS16355 3506745..3506948 + 204 WP_002208622.1 expression modulating protein YmoA Toxin
GD372_RS16365 3507836..3508225 + 390 WP_002208623.1 MGMT family protein -
GD372_RS16370 3508361..3508882 - 522 WP_002208624.1 lipoprotein -
GD372_RS16375 3509139..3509999 + 861 WP_002208625.1 acyl-CoA thioesterase II -
GD372_RS16380 3510259..3511548 - 1290 WP_002228344.1 ammonium transporter AmtB -
GD372_RS16385 3511588..3511926 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T141577 WP_002208622.1 NZ_CP045258:3506745-3506948 [Yersinia pestis]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T141577 NZ_CP060015:5260757-5261155 [Mycobacterium malmoense]
ATGATCGTCGACACGTCGGTCTGGATTGAATTTCTGACCACCTCTGAGTCGCTCGCCAGCCGCTGGCTAGCAGATCGCAT
TGCCGCCAACTCGCAGGTGATCGTCCCTGAGGTCGTGATGATGGAACTGCTGATCGGTACGACCGACGAGTCCAAGGCAA
TACGGCGGAGGCGACTACTGCAACGGTTCAATATCGAGCCGTTTGCCCCCGTGCGGGACGCAGAAGATGCGGCCGCTATC
CACCGGCGCTGTCGTCGCGGTGGTGACACCGTACGCAGCCTGATCGATTGCCAGGTGGCCGCGATGGCGCTGCGGATCGG
GGTCACTGTGGCACATCGTGATCGTGATTACGAGGTGATCCGCACGCATTGCGGACTACAAACCGAGCCCTTGTTCTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14215.00 Da        Isoelectric Point: 4.6121

>AT141577 WP_002218472.1 NZ_CP045258:3506328-3506696 [Yersinia pestis]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWINDPTSAINLQLNDLIEHIASFVMSFKIKYPDGSQLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKEHLFRLFSGEYVCTLMKT

Download         Length: 369 bp

>AT141577 NZ_CP060015:5260529-5260756 [Mycobacterium malmoense]
ATGTCGCGGACCAACATCGAAATCAACGACGAACTTGTGGCCGCCGCGCAGCGAATGTATCGACTGGATTCGAAGCGGAG
TGCCGTTGACCTCGCACTGCGCAGGCTCGTGGGTGAACCGTTAGACCGCGATGAGGCGTTGGCACTCCAGGGCAGCGGTT
TCGATTTCACCAATGATGAGATCGAATCGTTTTCGGACACGGGCATAGACCTCGCAGACCAGTCTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB Q66DR4

References