Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /COG5642-COG5654
Location 2259953..2260919 Replicon chromosome
Accession NZ_CP045258
Organism Yersinia pestis strain SCPM-O-B-5942 (I-2638)

Toxin (Protein)


Gene name - Uniprot ID A0A0E8XJV6
Locus tag GD372_RS10590 Protein ID WP_002210981.1
Coordinates 2260461..2260919 (+) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q66A69
Locus tag GD372_RS10585 Protein ID WP_002210982.1
Coordinates 2259953..2260399 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GD372_RS10565 2255542..2256516 - 975 WP_002210985.1 L-Ala-D/L-Glu epimerase -
GD372_RS10570 2256679..2257182 + 504 WP_002210984.1 thiol peroxidase -
GD372_RS10575 2257435..2257893 + 459 WP_002213775.1 IS200/IS605-like element IS1541B family transposase -
GD372_RS10580 2258040..2259617 - 1578 WP_002210983.1 transcriptional regulator TyrR -
GD372_RS10585 2259953..2260399 + 447 WP_002210982.1 DUF2384 domain-containing protein Antitoxin
GD372_RS10590 2260461..2260919 + 459 WP_002210981.1 RES family NAD+ phosphorylase Toxin
GD372_RS10595 2260929..2261990 - 1062 WP_002210980.1 YcjF family protein -
GD372_RS10600 2261987..2263384 - 1398 WP_002210979.1 YcjX family protein -
GD372_RS10605 2263365..2263607 - 243 WP_002216375.1 phage shock protein PspD -
GD372_RS10610 2263692..2264051 - 360 WP_002210977.1 envelope stress response membrane protein PspC -
GD372_RS10615 2264051..2264278 - 228 WP_002210976.1 envelope stress response membrane protein PspB -
GD372_RS10620 2264440..2265105 - 666 WP_002210975.1 phage shock protein PspA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2257435..2257893 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(2-147)

Antitoxin

Antitoxin Xre

(15-147)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 16994.38 Da        Isoelectric Point: 4.8732

>T141576 WP_002210981.1 NZ_CP045258:2260461-2260919 [Yersinia pestis]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Download         Length: 459 bp

>T141576 NZ_CP060015:c4441154-4440765 [Mycobacterium malmoense]
GTGATGGTTCGGCGGGCCCTCGCCGACACGTCCATCTTCATCGGGATCGAGGCGGCACGATTCGACGACGACCGATTTAC
CGAACACGAGTGGGGCGTCTCGGTGATCACACTGGGTGAGCTGCGGCTGGGTGTCCTGCAAGCCAGTGACCCGGACACCG
CCGCACGCCGGCTCTCCACATACCAGCTTGCTCAGCGGTTCGAACCACTGAGCATCGACGAGACGGTCTCCGAAGCGTGG
GCATTGCTGGTATCCAAGCGCGCCGCCAACCTGCGAGCACCGATCAACGACAGTTGGATTGCGGCAACTGCCATGGCGCA
TGGCATTCCGATCGTGACCCAGGGCAGCGACTACTCTGCGATGCCAGGCGTTGAGGTCATAACAATCTGA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16401.94 Da        Isoelectric Point: 9.7155

>AT141576 WP_002210982.1 NZ_CP045258:2259953-2260399 [Yersinia pestis]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Download         Length: 447 bp

>AT141576 NZ_CP060015:c4441408-4441151 [Mycobacterium malmoense]
ATGGCTGCTACGATACCCGCCCGCGATCTCCGTAACCGCACCGCTGAGGTGCTGCGGCGAGTTGCGGCAGGCGAGGAGAT
CGAGGTGCTCAAGGACAACCGTCCTGTGGCGCGCATAGTCCCACTCACACGGCGCCGCCAATGGCTACCGGCAGCGGAGG
TAATCGGCGAACTCATGCGCCTGGGTCCCGATACCACCAACCTCAGCGAGGAACTACGGGAGACGCTGACACGGACCACG
GACGACGTGTCGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E8XJV6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XFL1

References