Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 1694291..1694937 Replicon chromosome
Accession NZ_CP045258
Organism Yersinia pestis strain SCPM-O-B-5942 (I-2638)

Toxin (Protein)


Gene name hicA Uniprot ID A0A3G5L3F2
Locus tag GD372_RS07885 Protein ID WP_002214976.1
Coordinates 1694755..1694937 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0U1R391
Locus tag GD372_RS07880 Protein ID WP_002211129.1
Coordinates 1694291..1694710 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GD372_RS07860 1689362..1690357 + 996 WP_002211125.1 substrate-binding domain-containing protein -
GD372_RS07865 1690423..1692000 + 1578 WP_002211126.1 sugar ABC transporter ATP-binding protein -
GD372_RS07870 1692003..1693025 + 1023 WP_002214974.1 ABC transporter permease -
GD372_RS07875 1693074..1694033 + 960 WP_002211128.1 sugar kinase -
GD372_RS07880 1694291..1694710 - 420 WP_002211129.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GD372_RS07885 1694755..1694937 - 183 WP_002214976.1 type II toxin-antitoxin system HicA family toxin Toxin
GD372_RS07890 1695144..1695926 - 783 WP_002211130.1 flagellar type III secretion system protein FliR -
GD372_RS07895 1695929..1696198 - 270 WP_002211131.1 flagellar biosynthesis protein FliQ -
GD372_RS07900 1696304..1697044 - 741 WP_002220494.1 flagellar type III secretion system pore protein FliP -
GD372_RS07905 1697125..1697661 - 537 WP_002211133.1 flagellar biosynthetic protein FliO -
GD372_RS07910 1697661..1698077 - 417 WP_002211134.1 flagellar motor switch protein FliN -
GD372_RS07915 1698074..1699075 - 1002 WP_002211135.1 flagellar motor switch protein FliM -
GD372_RS07920 1699081..1699551 - 471 WP_002227961.1 flagellar basal body-associated protein FliL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-131)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6783.99 Da        Isoelectric Point: 10.8877

>T141575 WP_002214976.1 NZ_CP045258:c1694937-1694755 [Yersinia pestis]
VKSSELIKLLETNGWKLMRVKGSHHQFKHPDFAAVITVPHPKKDVKPGTLRQILKDANLS

Download         Length: 183 bp

>T141575 NZ_CP060015:4390102-4390500 [Mycobacterium malmoense]
GTGATCGTGGATACTTCGGCGGTCATCGCGATCCTCACAGAAGAGGACGACGCCGCCGTCTACGCCGAGGCCCTTGCCGG
CGCGGACACCTGCAGACTGTCAGCGGCCAGCTACCTCGAATGCGGGATCGTCCTAGATTCCCAGCGTGACCCGATCATTA
GCAGAGCGCTCGATGAACTCATGCAGGAAGCCCAATGCGTAGTCGAGCCGGTAACCGAGCGCCAGGCCCGTCTGGCCCGC
CAAGCGTATGCAGATTTCGGCAAAGGCAGCGGGCACCCGGCGGGTTTGAACTTCGGTGATTGCCTCTCGTACGCGCTGGC
GTCCGACCTACGCGAGCCCCTGCTATGGAAAGGCAACGACTTTGGGTATACGGGCATCAGGTCGGCGCTGGATCAGTAG

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15549.42 Da        Isoelectric Point: 4.7731

>AT141575 WP_002211129.1 NZ_CP045258:c1694710-1694291 [Yersinia pestis]
MAIYPAYVHVDNDGSASGYFPDVKGCIFAINAGEDLFAEASSALDAHFEALVSEGIEIPEAHDMPYHVYRNPCDYADGGQ
WYNVNIDMSKYDGKVERINVTLPHRLIHQIDTIVKVRPEYASRSNFLAEAARKELQKLA

Download         Length: 420 bp

>AT141575 NZ_CP060015:4389860-4390105 [Mycobacterium malmoense]
ATGGCTTTGAACATCAAAGATGCGTCGATCCACGAAGCGGTCAAGCAAATCGCGAAAATCACGGGTGAGTCCCAGACCCA
GGCCGTGGCGACCGCGGTGCAGGAGCGCCTGGCTCGACTGCAACGGGACGATCTCACGGCCCGGATTCTGGCAATCGGCC
ACAAGACTGCGGGCCGGATGAGCTCGGAGACCAAGCAGCTGGACCACGCCACGCTGCTCTACGATCAGCGAGGGCTTCCG
GCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G5L3F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1R391

References